22460-53-3Relevant academic research and scientific papers
CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2
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Page/Page column 102, (2012/01/06)
The present invention comprises compounds of Formula (I). Wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
Comprehensive kinetic and mechanistic considerations for the gas-phase behaviour of pinane-type compounds
Stolle, Achim,Ondruschka, Bernd,Bonrath, Werner
, p. 2310 - 2317 (2008/02/08)
The thermal behaviour of selected pinane-type compounds, α-pinene (1), β-pinene (2), pinane (3) and nopinone (4), has been investigated. The conversion of the bicyclic starting materials to their acyclic and monocyclic isomers as well as the consecutive reactions of the acyclic main isomerisation products are discussed. The conversion of 1-4 in a reaction network is presented and the experimental evidence for the formation of pyrolysis products by a biradical pathway is discussed. In addition to these results a kinetic model describing the isomerisation of the bicyclic compounds to their acyclic and monocyclic isomers is presented. A good correlation between kinetic simulations and experimental data is revealed. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides
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, (2008/06/13)
Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides The invention relates to (I) STR1 in which R1 to R5, A, X, E, U, p and n are as defined in claim 1, to processes for t
Synthetic Approach to the Amphilectane Diterpenes: The Use of Nitriles as Terminators of Carbocation-Olefin Cyclizations
Stevens, Robert V.,Albizati, Kim F.
, p. 632 - 640 (2007/10/02)
A biomimetic approach to the synthesis of tricyclic terpenoid isonitriles from marine sponges is described which involves carbocation-olefin cyclization of polyolefinic precursors terminated by the stereoselective formation of a carbon-nitrogen bond.The k
