804500-78-5

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3,6-dihydro-, 1,1-dimethylethyl ester, (3R)-
• CAS NO: 804500-78-5
• Molecular Formula: C26H35NO3Si
• Molecular Weight: 437.654
• Mol File: 804500-78-5.mol

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3,6-dihydro-, 1,1-dimethylethyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3,6-dihydro-, 1,1-dimethylethyl ester, (3R)-(804500-78-5)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3,6-dihydro-, 1,1-dimethylethyl ester, (3R)-(804500-78-5)

Safety Data

• Hazardous Substances Data: 804500-78-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 224779-26-4 N-allyl-N-(2-hydroxy-but-3-enyl)-carbamic acid tert-butyl ester 
• 780782-21-0 (R)-N-tert-butoxycarbonyl-5-acetoxy-3-piperidene 
• 224779-27-5 tert-butyl 3-hydroxy-1,2,3,6-tetrahydropyridine-N-carboxylate 
• 804500-75-2 t-butyl N-allyl-N-[(2R,3E)-2-(t-butyldiphenylsilyl)oxy-pent-3-en-1-yl]carbamate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 780782-29-8 tert-butyl (R)-3-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate 

Downstream Products

• 275363-98-9 (3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)piperidine 
• 858614-93-4 (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-methylpiperidine 
• 858614-91-2 (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-vinylpiperidine 
• 866923-70-8 (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-(hydroxymethyl)piperidine 
• 866923-72-0 (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-(2-hydroxyethyl)piperidine 
• 858614-87-6 (3S,4S,5S)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4,5-epoxypiperidine 

Relevant articles and documents

Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors

We report the structure-activity relationship of a series of d-, and l-isofagomine and fagomine isomers as glycosidase inhibitors. Our study revealed that a positive charge at the anomeric position of d-isofagomines enhanced the potency toward β-glycosida

A new route to diverse 1-azasugars from N-Boc-5-hydroxy-3-piperidene as a common building block

A new general method for the synthesis of a variety of 1-azasugars with a nitrogen atom at the anomeric position is described. The readily available chiral N-Boc-5-hydroxy-3-piperidene 3 is transformed to isofagomine (2), homoisofagomine (13), and 5′-deox

Conversion of chiral unsaturated cyanohydrins into chiral carba- and heterocycles via ring-closing metathesis

Aliphatic unsaturated cyanohydrins 1-3 served as starting materials in the synthesis of a set of new chiral unsaturated cyclic 1,2-ethanolamines. Combining a Grignard addition-NaBH4 reduction sequence with a ring-closing metathesis afforded uns

A short and concise synthesis of isofagomine, homoisofagomine, and 5′-deoxyisofagomine

A short and concise synthesis of isofagomine derivatives via the epoxidation of chiral N-Boc-5-hydroxy-3-piperidene, followed by regioselective epoxide ring opening is described. This constitutes the first reported synthesis of homoisofagomine and the 5′-