224785-98-2

Basic information

• Product Name: Hydroxyvardenafil
• Synonyms: Hydroxyvardenafil;2-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-5-Methyl-7-propyliMidazo[5,1-f][1,2,4]triazin-4(1H)-one;4-[[3-(1,4-Dihydro-5-Methyl-4-oxo-7-propyliMidazo [5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol;Vardenafil impurity C;Hydroxy Vardenafil Solution, 100ppm
• CAS NO: 224785-98-2
• Molecular Formula: C₂₃H₃₂N₆O₅S
• Molecular Weight: 504.60238
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 224785-98-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 9.86±0.20(Predicted)
• CAS DataBase Reference: Hydroxyvardenafil(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxyvardenafil(224785-98-2)
• EPA Substance Registry System: Hydroxyvardenafil(224785-98-2)

Safety Data

• Hazardous Substances Data: 224785-98-2(Hazardous Substances Data)

Usage

Uses

Vardenafil (V098001) derivative as PDE 5 inhibitor.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 224789-26-8 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride 

Relevant articles and documents

2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors

The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.