22480-91-7

Basic information

• Product Name: 2,3,4-TRIMETHOXYPHENYLACETIC ACID
• Synonyms: RARECHEM AL BO 0583;SALOR-INT L497746-1EA;LABOTEST-BB LT00233193;2,3,4-TRIMETHOXYPHENYLACETIC ACID;Benzeneacetic acid, 2,3,4-trimethoxy-;2,3,4-Trimethoxybenzeneacetic acid
• CAS NO: 22480-91-7
• Molecular Formula: C₁₁H₁₄O₅
• Molecular Weight: 226.23
• EINECS: 245-024-4
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 22480-91-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 349 °C at 760 mmHg
• Flash Point: 132.6 °C
• Appearance: /
• Density: 1.197 g/cm³
• Vapor Pressure: 1.81E-05mmHg at 25°C
• CAS DataBase Reference: 2,3,4-TRIMETHOXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHOXYPHENYLACETIC ACID(22480-91-7)
• EPA Substance Registry System: 2,3,4-TRIMETHOXYPHENYLACETIC ACID(22480-91-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22480-91-7(Hazardous Substances Data)

Usage

General Description

2,3,4-Trimethoxyphenylacetic acid is a chemical compound with the molecular formula C11H14O5. It is a derivative of phenylacetic acid and contains three methoxy groups attached to the phenyl ring at the 2, 3, and 4 positions. 2,3,4-TRIMETHOXYPHENYLACETIC ACID is often used as a building block in organic synthesis, particularly in the production of pharmaceuticals and other fine chemicals. It has been studied for its potential biological activities, including anti-inflammatory and analgesic properties. Additionally, 2,3,4-Trimethoxyphenylacetic acid has been investigated for its potential use as a precursor in the synthesis of natural products and biologically active compounds.

InChI:InChI=1/C11H14O5/c1-14-8-5-4-7(6-9(12)13)10(15-2)11(8)16-3/h4-5H,6H2,1-3H3,(H,12,13)/p-1

Upstream product

• 68913-85-9 2-(2,3,4-trimethoxyphenyl)acetonitrile 
• 22558-28-7 2-phenyl-4-(2,3,4-trimethoxy-benzylidene)-4H-oxazol-5-one 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 13909-73-4 2',3',4'-trimethoxyacetophenone 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 

Downstream Products

• 22480-88-2 methyl 2,3,4-trimethoxyphenylacetate 
• 1404301-47-8 3-(3,4,5-trimethoxyphenyl)-2H-chromen-2-one 
• 99339-44-3 trimethoxyphenethyl alcohol 
• 153851-90-2 2,3,4-Trimethoxyphenyl-N-(2-(2,3,4-trimethoxyphenyl)ethyl)-acetamide 
• 864518-31-0 C₂₅H₂₇NO₆S 
• 79659-47-5 O-methylpolycarpine 

Relevant articles and documents

Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1

Synthetic scheme for the preparation of a number of different derivatives of anticancer natural product Psoralidin is described. A convergent synthetic approach is followed using simple starting materials like substituted phenyl acetic esters and benzoic acids. The developed synthetic route leads us to complete the first synthesis of an analogous natural product Lespeflorin I1, a mild melanin synthesis inhibitor. Preliminary bioactivity studies of the synthesized compounds are carried out against two commonly used prostate cancer cell lines. Results show that the bioactivity of the compounds can be manipulated by the simple modification of the functional groups.

Synthesis of the novel isoquinoline enamide alkaloid polycarpine

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