224819-17-4Relevant academic research and scientific papers
One-pot synthesis of 4,6-Diaryl-2-oxo(imino)-1,2-dihydropyridine-3- carbonitrile; A new scaffold for p38α MAP kinase inhibition
Serry, Aya M.,Luik, Sabine,Laufer, Stefan,Abadi, Ashraf H.
experimental part, p. 559 - 565 (2010/09/05)
Two series of new compounds with the general formula 4,6-diaryl-2-oxo-1,2- dihydropyridine-3-carbonitriles and their isosteric 2-imino derivatives were synthesized by the multicomponent reaction of the appropriate acetophenone, aromatic aldehyde, ammonium acetate, and malononitrile or ethyl cyanoacetate. The products were obtained with excellent yields. The prepared compounds were evaluated for their in vitro ability to inhibit p38 α-MAP kinase. Several compounds showed p38 MAP kinase inhibitory properties with IC50 as low as 0.07 μM. This is the first time to report compounds with such scaffold as p38 α-MAP kinase inhibitors. This asserts the potentiality of multicomponent reactions in drug discovery.
Ecofriendly synthesis of substituted pyridine and pyrido[2,3-d]pyrimidine derivatives
Kidwai,Thakur,Rastogi
, p. 1523 - 1526 (2007/10/03)
An environmentally benign novel one-pot synthesis of pyridines and pyrido[2,3-d]pyrimidines from chalcones and malononitrile was described. In the reaction under neat conditions using microwave irradiation, enhancement in the reaction rate and high yields
Anti-inflammatory, analgesic and antipyretic 4,6-disubstituted 3-cyano- 2-aminopyridines
Manna, Fedele,Chimenti, Franco,Bolasco, Adriana,Bizzarri, Bruna,Filippelli, Walter,Filippelli, Amelia,Gagliardi, Luigi
, p. 245 - 254 (2007/10/03)
4,6-diaryl and 4,6-aryl-indolyl substituted 3-cyano-2-aminopyridines were synthesized and submitted to evaluation for their anti-inflammatory, analgesic and antipyretic activity. The electronegativity of the substituents and their displacement on the 4- o
