22490-64-8

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 175840-02-5 6-trifluoromethanesulfonyloxyindan-1-one 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 20854-61-9 4-(bromomethyl)-4'-methoxy-1,1'-biphenyl 
• 729-17-9 methyl 4-(4'-methoxyphenyl)benzoate 
• 20854-60-8 (4'-methoxy[1,1'-biphenyl]-4-yl)methanol 
• 14548-39-1 6-bromoindan-1-one 
• 20854-62-0 3-(4-(4-methoxyphenyl)phenyl)propanoic acid 

Downstream Products

• 20854-64-2 6--indanol-(1) 
• 20854-67-5 6--2-oximino-indanon-(1) 
• 20902-20-9 6--trans-indandiol-(1,2) 
• 395682-02-7 2-(4-hydroxybenzyl)-2-hydroxymethyl-6-(4-hydroxyphenyl)-indan-1-one 
• 395682-00-5 2-hydroxymethyl-2-(4-methoxybenzyl)-6-(4-methoxyphenyl)-indan-1-one 
• 395681-99-9 2-(4-methoxybenzyl)-6-(4-methoxyphenyl)-indan-1-one 

Relevant academic research and scientific papers

Chemical studies on the chiral indanone derivatives as the inhibitor of Renilla luciferase

The bioluminescence reaction of coelenterazine involves an oxidative process. To investigate the reaction mechanism, we synthesized three mechanism-based inhibitors with an indanone core structure. The inhibitors exhibited the competitive inhibition of the Renilla luciferase reaction. The (-)-4-benzyl-2-(4-hydroxybenzyl)-2-hydroxymethyl-6-(4-hydroxyphenyl)-indan- 1-one showed the significant enantio-selectivity of the inhibition and its absolute configuration was assigned as the R-configuration. These inhibitors could be useful probes to study the catalytic environment in the coelenterazine-luciferase reaction.

Synthetic studies of novel ninhydrin analogs

Ninhydrin is an essential tool in the analysis of amino acids, peptides, and proteins, and the preferred reagent for the detection of latent fingerprints on porous surfaces. The goal of this investigation was to prepare ninhydrin analogs with enhanced chromogenic and fluorogenic properties. Target compounds included structures with extended conjugation and (or) with the presence of sulfur-containing moieties. We have devised general convergent routes for novel heterocyclic and aryl-substituted ninhydrin analogs for use as reagents for amino acid detection.