22509-56-4Relevant academic research and scientific papers
Cascade radical reaction of substrates with a carbon-carbon triple bond as a radical acceptor
Miyabe, Hideto,Asada, Ryuta,Takemoto, Yoshiji
, p. 1148 - 1155 (2013)
The limitation of hydroxamate ester as a chiral Lewis acid coordination moiety was first shown in an intermolecular reaction involving a radical addition and sequential allylation processes. Next, the effect of hydroxamate ester was studied in the cascade
Organocatalytic Aza-Michael/Michael Cyclization Cascade Reaction: Enantioselective Synthesis of Spiro-oxindole Piperidin-2-one Derivatives
Tang, Qing-Gang,Cai, Sen-Lin,Wang, Chuan-Chuan,Lin, Guo-Qiang,Sun, Xing-Wen
supporting information, p. 3351 - 3355 (2020/04/21)
A simple, direct, and highly enantioselective synthesis of spiro-oxindole piperidin-2-one derivatives was achieved through an aza-Michael/Michael cyclization cascade sequence using a squaramide catalyst. The desired products were obtained in excellent yields (up to 99%) and good to high stereoselectivities (up to >20:1 dr and up to 99% ee) under mild conditions.
