22518-00-9

Usage

Preparation

By acidic hydrolysis of two esters isolated from Gaillardia aristata, the 7-isobutyryloxy-8,9-epoxythymol and 7-(2-methylbutyryloxy)-8,9-epoxythymol isobutyrates.

Upstream product

• 112920-14-6 2-acetoxy-4-methylacetophenone 
• 848566-04-1 1-[2-acetoxy-4-(bromomethyl)phenyl]ethan-1-one 

Downstream Products

• 848566-05-2 6-methyl-2-[2-(triisopropylsilanyloxy)-4-(triisopropylsilanyloxymethyl)phenyl]hept-5-en-2-ol 
• 848566-06-3 4-dimethyloxiranyl-2-[2-(triisopropylsilanyloxy)-4-(triisopropylsilanyloxymethyl)phenyl]butan-2-ol 
• 848645-06-7 1-[2-(triisopropylsilanyloxy)-4-(triisopropylsilanyloxymethyl)phenyl]ethan-1-one 

Relevant academic research and scientific papers

Isolation, structural elucidation, and synthesis of curcutetraol

The new natural products (+)-curcutetraol and (-)-curcutriolamide were isolated from the bacterium CNH-741 and the fungus CNC-979, isolated from marine sediment. (+)-Curcutetraol is a polar compound and contains a tertiary benzylic alcohol moiety at the single stereogenic center, which was retained without racemization by avoiding chromatography on silica. The absolute configuration of (+)-curcutetraol was determined by comparison of its experimental CD spectrum with the spectra predicted by quantum-chemical CD calculations. Phenolic bisabolane sesquiterpenoids from marine sources were previously known only from gorgonians and sponges. A short total synthesis of racemic curcutetraol has been developed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.