225233-53-4

Upstream product

• 98-88-4 benzoyl chloride 
• 225233-51-2 4-C-ethynyl-1,2-O-isopropylidene-3,5-di-O-p-methoxybenzyl-α-D-ribo-pentofuranose 
• 154799-94-7 3-O-(4-Methoxybenzyl)-1,2-O-isopropylidene-4-formylerythrofuranose 
• 225233-50-1 4-C-(2,2-dibromoethenyl)-1,2-O-isopropylidene-3,5-di-O-p-methoxybenzyl-α-D-ribo-pentofuranose 
• 225233-48-7 4-C-hydroxymethyl-1,2-O-isopropylidene-3,5-di-O-p-methoxybenzyl-α-D-ribo-pentofuranose 
• 225233-49-8 4-C-formyl-1,2-O-isopropylidene-3,5-di-O-p-methoxybenzyl-α-D-ribo-pentofuranose 
• 225233-47-6 ((3aR,6S,6aR)-6-((4-methoxybenzyl)oxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5,5-diyl)dimethanol 
• 2595-05-3 Diacetone D-glucose 
• 69940-02-9 3-O-(4-Methoxybenzyl)-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 69940-04-1 (R)-1-[(3aR,5R,6R,6aR)-6-(4-methoxybenzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol 

Downstream Products

• 1030595-51-7 C₂₂H₂₀O₇ 

Relevant academic research and scientific papers

2'-FLUORO-4'-SUBSTITUTED NUCLEOSIDES, THE PREPARATION AND USE

The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: wherein: R = CH3, CH, N3, C≡CH; R' = H, F; X = F, OH, NH2; Y = H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

Synthesis of 4′-C-ethynyl-β-D-ribo-pentofuranosyl pyrimidines

The 4′-C-ethynyl-β-D-ribo-pentofuranosylpyrimidines were prepared from D-glucose through properly protected 4′-C-formyl-D-ribo-ribofuranose as the key intermediate, and preliminary biological tests against some viruses and tumor cells showed that the comp