225245-08-9

Upstream product

• 3277-89-2 phenethylmagnesium bromide 
• 58701-44-3 17-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 521-18-6 Stanolone 
• 42808-98-0 phenethyllithium 

Downstream Products

• 863659-65-8 17β-[(tert-butyldimethylsilyl)oxy]-3α-methoxy-3β-(2'-phenylethyl)-5α-androstane 

Relevant academic research and scientific papers

Androsterone 3α-ether-3β-substituted and androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Chemical synthesis and structure - Activity relationship

Type 3 17β-hydroxysteroid dehydrogenase (17β-HSD) is involved in the biosynthesis of androgen testosterone. To produce potent inhibitors of this key steroidogenic enzyme, we prepared a series of androsterone (ADT) derivatives by adding a variety of substi

Inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase and methods for their use

Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17β-hydroxysteroid dehydrogenase. Novel inhibitors of type 5 17β-hydroxysteroid dehydrogenase are also disclosed, as are novel inhibitors of type 3 17β-hydroxysteroid dehydrogenase.

Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase.

Androsterone derivatives substituted at position 3 were synthesized starting from dihydrotestosterone in a short sequence of reactions. They proved to be potent inhibitors (IC50 = 57-147 nM) of type 3 17beta-hydroxysteroid dehydrogenase, a key enzyme of s

Diastereoselective addition of organomagnesium reagents to 17β-TBDMS- dihydrotestosterone

Several alkylations of the C3-carbonyl of 17β-TBDMS-DHT (1) with Grignard reagents were performed to obtain a series of potential inhibitors of androgen formation. It has been found that, depending on the nucleophilicity of the Grignard reagent used, there was a difference in the diastereoselectivity. The stronger reagents proceeded preferentially through the equatorial attack, while the weaker ones proceeded through the axial attack.