22525-90-2Relevant academic research and scientific papers
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
Allwood, Daniel M.,Blakemore, David C.,Brown, Alan D.,Ley, Steven V.
, p. 328 - 338 (2014/01/17)
The coupling of aromatic moieties with saturated heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step synthesis of a range of functionalized sp2-sp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.
Synthesis and Antineoplastic Activity of Phenyl-Substituted Benzenesulfonylhydrazones of 2-Pyridinecarboxaldehyde 1-Oxide
Loh, William,Cosby, Lucille A.,Sartorelli, Alan C.
, p. 631 - 634 (2007/10/02)
A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine ring as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized.The antine
