22531-59-5Relevant academic research and scientific papers
CONDENSED RING DERIVATIVE, AND PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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Paragraph 0138; 0139, (2018/02/28)
Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
Thiophene amide structure-containing compounds and application thereof
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Paragraph 0028; 0031; 0032, (2018/05/16)
The invention relates to the field of medicines, in particular to thiophene amide structure-containing compounds, a preparation method thereof and application thereof to preparation of medicines for treating inflammatory diseases, eye diseases, respiratory diseases and the like.
Derivative comprising thiopheneamide structure, preparation method and application
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Paragraph 0031; 0032; 0035; 0036, (2018/06/26)
The invention relates to the field of medicine, in particular to a derivative comprising a thiopheneamide structure, a preparation method thereof and application to preparation of drugs for treating inflammatory diseases, eye diseases, respiratory system diseases and the like. (the derivative is shown in the description), R is selected from alkyl of C1 to C5, and naphthenic base of C3 to C6.
Compound comprising isopropylamine and nitrothiophene amide structure as well as preparation method and application thereof
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Paragraph 0028; 0031; 0032, (2018/06/26)
The invention relates to the field of medicine, in particular to a compound of an isopropylamine and nitrothiophene amide structure as well as a preparation method thereof and application thereof to preparation of drugs for treating inflammatory diseases, eye diseases, respiratory system diseases and the like. (The compound is shown in the description.).
Nitrothiophene amide ROCK inhibitor and preparing method and application thereof
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Paragraph 0028; 0031-0032, (2018/07/03)
The invention relates to the field of ROCK inhibitors, in particular to a nitrothiophene amide ROCK inhibitor, and a preparing method and application thereof in preparing drugs for treating diseases like sexual dysfunction. The formula of the nitrothiophene amide ROCK inhibitor is shown in the description.
Thiophene amide type ROCK inhibitor, preparation method and application thereof
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Paragraph 0030; 0031; 0034; 0035, (2018/07/06)
The invention relates to the field of ROCK inhibitors. Specifically, the invention relates to a thiophene amide type ROCK inhibitor, a preparation method and the application thereof in the treatment of sexual dysfunction, inflammatory diseases, ophthalmic diseases, respiratory system diseases and the like. The formula is as shown in the specification, wherein R is selected from an alkyl group of C1 to C5 and a naphthenic group of C3 to C6.
Compound containing isopropylamine and nitrile thiophene amide structures
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Paragraph 0028; 0031; 0032, (2018/07/30)
The invention relates to the field of medicine, in particular to a compound containing isopropylamine and nitrile thiophene amide structures, a preparation method thereof, and application thereof to preparation of medicine for treating inflammatory diseases, ophthalmic diseases and respiratory system diseases.
Thiophene amide ROCK (Rho-associated protein kinase) inhibitor as well as preparation method and application thereof
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Paragraph 0028; 0031; 0032, (2018/07/30)
The invention relates to the field of ROCK (Rho-associated protein kinase) inhibitors, in particular to a thiophene amide ROCK inhibitor, a preparation method thereof and an application to preparationof drugs for treating sexual dysfunction, inflammatory diseases, eye diseases, respiratory diseases and the like.
Isopropylamine thiophenamide structural compound, preparation method and application thereof
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Paragraph 0030; 0031; 0034; 0035, (2018/07/30)
The invention relates to the field of medicines, in particular to an isopropylamine thiophenamide structural compound, a preparation method thereof and application thereof to preparation of the medicines for treating inflammatory diseases, ophthalmic diseases, respiratory diseases and the like. In a formula shown in the description, R is selected from C1-C5 alkyls.
A kind of thiophene amide ROCK inhibitors, preparation method and use thereof (by machine translation)
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Paragraph 0028; 0029; 0032; 0033; 0041; 0045; 0053; 0057, (2018/07/15)
The present invention relates to the field of ROCK inhibitors. Specifically, the invention relates to a thiophene amide ROCK inhibitor, its preparation method and in the production of therapeutic dysfunction and other diseases application of the medicament. Wherein X is selected from F, Cl substituent. (by machine translation)
