129278-20-2Relevant academic research and scientific papers
A new solvatochromic fluorophore for exploring nonpolar environments created by biopolymers
Fakhari M., Abulfazl,Rokita, Steven E.
, p. 4222 - 4224 (2011)
The fluorescence of a new aminocyanonaphthalene exhibits exquisite sensitivity to its environment and responds to a solvent change from water to hexane with greater than a 100-fold increase in intensity and 100 nm shift in λmax.em. These properties should support many applications including the detection of abasic sites within duplex DNA as illustrated below.
Chiral Selenide/Achiral Sulfonic Acid Cocatalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence
Luo, Hui-Yun,Li, Zi-Hao,Zhu, Deng,Yang, Qin,Cao, Ren-Fei,Ding, Tong-Mei,Chen, Zhi-Min
supporting information, p. 2943 - 2952 (2022/02/23)
Enantioselective synthesis of axially chiral sulfur-containing biaryl derivatives through the electrophilic sulfenylation of biaryl phenols has been achieved for the first time. This catalytic asymmetric system, which involves sequential desymmetrization and kinetic resolution, is enabled by a combination of a novel 3,3′-disubstituted BINOL-derived selenide catalyst and an achiral sulfonic acid. Control experiments and computational studies suggest that multiple noncovalent interactions between the cocatalysts and substrate, especially a network of hydrogen bond interactions, play a crucial role in determining the enantioselectivity and reactivity.
CONDENSED RING DERIVATIVE, AND PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
-
, (2018/02/28)
Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
SRN1 SYNTHESES OF BIS(PHENYLTHIO)- AND DICYANO-NAPHTHALENES VIA DIAZOSULFIDES
Novi, M.,Garbarino, G.,Petrillo, G.,Dell'Erba, C.
, p. 2205 - 2212 (2007/10/02)
The reactions of bromonaphthalenediazonium tetrafluoroborates (6a,b and 11a,b) with sodium benzenethiolate in DMSO give, through the preliminary formation of the corresponding diazosulfides (7a,b and 12a,b) bis(phenylthio)naphthalenes (8a,b and 13a,b) deriving from substitution of both the diazo group and the bromine.Isolated diazosulfides (7a,b and 12a,b) likewise furnish satisfactory yields of dinitriles (9a,b and 14a,b) by reaction with excess tetrabutylammonium cyanide in DMSO under photostimulation by a sunlamp.The intervention of an SRN1 process accounting for the formation of the disubstitution products is postulated.
