22539-65-7

Basic information

• Product Name: 1,2-dimethyl-3-(propan-2-yl)benzene
• Synonyms: 1-Isopropyl-2,3-dimethylbenzene; benzene, 1,2-dimethyl-3-(1-methylethyl)-
• CAS NO: 22539-65-7
• Molecular Formula: C₁₁H₁₆
• Molecular Weight: 148.2447
• Mol File: 22539-65-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 201.2°C at 760 mmHg
• Flash Point: 68.5°C
• Density: 0.861g/cm³
• Vapor Pressure: 0.442mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: 1,2-dimethyl-3-(propan-2-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethyl-3-(propan-2-yl)benzene(22539-65-7)
• EPA Substance Registry System: 1,2-dimethyl-3-(propan-2-yl)benzene(22539-65-7)

Safety Data

• Hazardous Substances Data: 22539-65-7(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong, aromatic

Uses

a. Solvent
b. Intermediate in the production of dyes, resins, and pharmaceuticals
c. Synthesis of various organic compounds

Solubility

Low in water

Flammability

Flammable in liquid state

Safety precautions

Handle with care and use proper safety measures when working with pseudocumene

Upstream product

• 108837-99-6 5-tert-butyl-1-isopropyl-2,3-dimethyl-benzene 
• 576-23-8 2,3-dimethylbromobenzene 
• 1888-75-1 isopropyllithium 
• 4132-77-8 3,4-dimethylcumene 
• 67-63-0 isopropyl alcohol 
• 95-47-6 o-xylene 

Relevant articles and documents

Palladium-catalysed direct cross-coupling of secondary alkyllithium reagents

Palladium-catalysed cross-coupling of secondary C(sp3) organometallic reagents has been a long-standing challenge in organic synthesis, due to the problems associated with undesired isomerisation or the formation of reduction products. Based on our recently developed catalytic C-C bond formation with organolithium reagents, herein we present a Pd-catalysed cross-coupling of secondary alkyllithium reagents with aryl and alkenyl bromides. The reaction proceeds at room temperature and on short timescales with high selectivity and yields. This methodology is also applicable to hindered aryl bromides, which are a major challenge in the field of metal catalysed cross-coupling reactions.