22547-46-2Relevant academic research and scientific papers
3-(4-Piperidinylalkyl)indoles, Selective Inhibitors of Neuronal 5-Hydroxytryptamine Uptake
Gueremy, Claude,Audiau, Francois,Champseix, Alain,Uzan, Andre,Fur, Gerard Le,Rataud, Jean
, p. 1306 - 1310 (2007/10/02)
A series 3-(4-piperidinylalkyl)indoles was synthesized and tested as uptake inhibitors of biogenic amines.Some of these compounds are potent and very selective in blocking the 5-hydroxytryptamine (5-HT) uptake, as evidenced by biochemical data and behavioral tests.A discussion on structure-activity relationships is given.The most interesting member of the series, indalpine, 3-indole (1), was selected for clinical studies.
