22547-51-9

Upstream product

• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 104-15-4 toluene-4-sulfonic acid 
• 60-34-4 methylhydrazine 
• 74-88-4 methyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 62655-41-8 Ethyliden-N-methyl-N-tosylhydrazon 
• 62655-42-9 isobutyraldehyde methyl-(toluene-4-sulfonyl)-hydrazone 
• 67406-87-5 Isopropyliden-N-methyl-N-tosylhydrazon 
• 73736-96-6 C₁₄H₁₅N₃O₃S 
• 102396-52-1 1-methyl-2-(4-nitrobenzoyl)-1-(4-tolylsulfonyl)hydrazine 
• 102396-49-6 2-(methylsulfonyl)-1-methyl-1-(4-tolylsulfonyl)hydrazine 
• 98394-31-1 N'-(p-chlorobenzenesulfonyl)-N-methyl-N-(p-toluenesulfonyl)hydrazine 
• 98394-29-7 N'-benzenesulfonyl-N-methyl-N-(p-toluenesulfonyl)hydrazine 
• 98394-30-0 N'-(p-methoxybenzenesulfonyl)-N-methyl-N-(p-toluenesulfonyl)hydrazine 
• 102396-50-9 2-(ethylsulfonyl)-1-methyl-1-(4-tolylsulfonyl)hydrazine 
• 98394-34-4 2-(α-tolylsulfonyl)-1-methyl-1-(4-tolylsulfonyl)hydrazine 
• 413582-57-7 salicylaldehyde-N-methyl p-toluenesulfonylhydrazone 
• 1616508-38-3 C₃₀H₃₀N₄O₆PdS₂ 

Relevant academic research and scientific papers

Synthesis, characterization, computational studies, antimicrobial activities and carbonic anhydrase inhibitor effects of 2-hydroxy acetophenone-N-methyl p-toluenesulfonylhydrazone and its Co(II), Pd(II), Pt(II) complexes

2-Hydroxyacetophenone-N-methyl p-toluenesulfonylhydrazone (afptsmh) derived from p-toluenesulfonicacid-1-methylhydrazide (ptsmh) and its Co(II), Pd(II), Pt(II) complexes were synthesized for the first time. Synthesized compounds were characterized by spec

N -aminopyridinium salts as precursors for N-centered radicals - Direct amidation of arenes and heteroarenes

Readily prepared N-aminopyridinium salts are valuable precursors for the generation of N-centered radicals. Reduction of these salts by single electron transfer allows for clean generation of amidyl radicals. It is shown that direct radical C-H amination of heteroarenes and arenes can be achieved with N-aminopyridinium salts under mild conditions by using photoredox catalysis.

Synthesis, characterization, antimicrobial activity and carbonic anhydrase enzyme inhibitor effects of salicilaldehyde-N-methyl p-toluenesulfonylhydrazone and its Palladium(II), Cobalt(II) complexes

We report the synthesis of the ligand, salicilaldehyde-N-methyl p-toluenesulfonylhydrazone (salptsmh) derived from p-toluenesulfonicacid-1- methylhydrazide (ptsmh) and its Pd(II) and Co(II) metal complexes were synthesized for the first time. The structure of the ligand and their complexes were investigated using elemental analysis, magnetic susceptibility, molar conductance and spectral (IR, NMR and LC-MS) measurements. Salptsmh has also been characterized by single crystal X-ray diffraction. 1H and 13C shielding tensors for crystal structure were calculated with GIAO/DFT/B3LYP/6-311++G(d,p) methods in CDCl3. The complexes were found to have general composition [ML2]. The results of elemental analysis showed 1:2 (metal/ligand) stoichiometry for all the complex. Magnetic and spectral data indicate a square planar geometry for Pd(II) complex and a distorted tetrahedral geometry for Co(II) complexes. The ligand and its metal chelates have been screened for their antimicrobial activities using the disk diffusion method against the selected Gram positive bacteria: Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Enterococcus faecalis, Gram negative bacteria: Eschericha coli, Pseudomonas aeruginosa, Klebsiella pneumonia. The inhibition activities of these compounds on carbonic anhydrase II (CA II) and carbonic anhydrase I (CA I) have been investigated by comparing IC50 and Ki values and it has been found that Pd(II) complex have more enzyme inhibition efficiency than salptsmh and Co(II) complex.

Synthesis of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2h-chromenes as potent antiproliferative and apoptosis inducing agents

3-Nitro-2H-chromenes have recently been identified as a novel class of potent antitumor agents. In view of the favorable effects shown by sulfonylhydrazones and acylhydrazones, we designed and synthesized a series of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2H-chromene derivatives, and evaluated their cell growth inhibition activities against A549, KG-1, A2780, and K562 cells. All the tested compounds exhibited more potent antiproliferative activity than BENC-511 against KG-1 cells. These compounds displayed IC50 values in the nanomolar range against A2780 cells. Compound 7d showed prominent cytotoxicity against K562 cells with an IC 50 of 0.11 μM, which was comparable to that of BENC-511. Compound 7d arrested K562 cells at the G1 phase at high concentrations and induced apoptosis in K562 cells. Furthermore, 7d increased the levels of cleaved caspase-3, decreased the expression of bcl-2 and induced the cleavage of poly(ADP-ribose) polymerase in K562 cells. Thus, this study provides the development of a series of novel compounds as effective antitumor agents with apoptotic death ability.