22551-91-3

Usage

Uses

Used in Organic Synthesis:
5-Acetyl-2-furoic acid methyl ester is used as a key intermediate in organic synthesis for the production of various organic compounds. Its unique structure and reactivity make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Acetyl-2-furoic acid methyl ester is used as a raw material for the development of new drugs. Its versatile chemical properties allow it to be incorporated into a wide range of pharmaceutical products, contributing to the discovery and synthesis of novel therapeutic agents.
Used in Biotechnology Industry:
5-Acetyl-2-furoic acid methyl ester is utilized in the biotechnology sector as a starting material for the production of bioactive compounds and other biotechnological applications. Its potential to be modified and functionalized makes it a promising candidate for the development of new bioproducts.
Used in Agrochemical Production:
5-Acetyl-2-furoic acid methyl ester is employed in the agrochemical industry for the synthesis of various agrochemical products, such as pesticides and herbicides. Its chemical properties enable it to be a part of the active ingredients in these products, contributing to their effectiveness in agricultural applications.
Used in Food Industry as Flavoring Ingredient:
Due to its pleasant odor, 5-Acetyl-2-furoic acid methyl ester is used as a flavoring ingredient in the food industry. It adds unique and desirable flavors to food products, enhancing their taste and consumer appeal.

Upstream product

• 600158-69-8 5-Diethoxymethyl-furan-2-carboxylic acid 
• 14003-12-4 5-methyl-furan-2-carboxylic acid ethyl ester 
• 13529-27-6 2-(diethoxymethyl)furan 
• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 75-03-6 ethyl iodide 
• 614-99-3 Ethyl 2-furoate 
• 76448-73-2 ethyl 5-(hydroxymethyl)furan-2-carboxylate 
• 64-17-5 ethanol 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 584-08-7 potassium carbonate 

Downstream Products

• 86238-82-6 (E)-1-(5-carboxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene 
• 86238-81-5 (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene 
• 4282-32-0 furan-2,5-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties

Urea transporters (UTs) have been identified as new targets for diuretics. Functional deletion of UTs led to urea-selective urinary concentrating defects with relative salt sparing. In our previous study, a UT inhibitor with a diarylamide scaffold, which is denoted as 11a, was demonstrated as the first orally available UT inhibitor. However, the oral bioavailability of 11a was only 4.38%, which obstructed its clinical application. In this work, by replacing the nitro group of 11a with an acetyl group, 25a was obtained. Compared with 11a, 25a showed a 10 times stronger inhibitory effect on UT-B (0.14 μM vs. 1.41 μM in rats, and 0.48 μM vs. 5.82 μM in mice) and a much higher inhibition rate on UT-A1. Moreover, the metabolic stability both in vitro and in vivo and the drug-like properties (permeability and solubility) of 25a were obviously improved compared with those of 11a. Moreover, the bioavailability of 25a was 15.18%, which was 3 times higher than that of 11a, thereby resulting in significant enhancement of the diuretic activities in rats and mice. 25a showed excellent potential for development as a promising clinical diuretic candidate for targeting UTs to treat diseases that require long-term usage of diuretics, such as hyponatremia.

Method for preparing 5-formyl-2-furancarboxylate

The invention discloses a method for preparing 5-formyl-2-furancarboxylate. The method is characterized in that the 5-formyl-2-furancarboxylate is prepared through a one-step reaction of furoate, usedas a raw material, in a solvent at a temperature of 0-100 DEG C under normal pressure with a Vilsmeier reagent and a Lewis acid as catalysts. The method has the advantages of high selectivity, good atom economy, high product yield, simple process route, and high additional values of the product. The method is harmless to the environment, is suitable for large-scale synthesis, and has a potentialindustrial application prospect.

Highly efficient and selective oxidation of 5-hydroxymethylfurfural by molecular oxygen in the presence of Cu-MnO2 catalyst

The selective oxidation of 5-hydroxymethylfurfural (HMF) to produce value-added chemicals is a hot topic in the utilization of biomass, in which the development of heterogeneous catalyst and the use of O2 as terminal oxidant is desired. In this work, a series of metal ion-doped MnO2 materials are successfully prepared using liquid precipitation method, and employed as catalysts for the aerobic oxidation of HMF in the alcoholic solvents. As a result, it is found that 86.0% conversion of HMF and 96.1% selectivity of 2,5-diformylfuran (DFF) was obtained under suitable conditions. Moreover, the Cu-MnO2 catalyst can keep a high activity after being recycled five times.

Synthesis of Furandicarboxylic Acid Esters From Nonfood Feedstocks Without Concomitant Levulinic Acid Formation

5-Hydroxymethylfurfural (HMF) is a versatile intermediate in biomass conversion pathways. However, the notoriously unstable nature of HMF imposes challenges to design selective routes to chemicals such as furan-2,5-dicarboxylic acid (FDCA). Here, a new strategy for obtaining furans is presented, bypassing the formation of the unstable HMF. Instead of starting with glucose/fructose and thus forming HMF as an intermediate, the new route starts from uronic acids, which are abundantly present in many agro residues such as sugar beet pulp, potato pulp, and citrus peels. Conversion of uronic acids, via ketoaldonic acids, to the intermediate formylfuroic acid (FFA) esters, and subsequently to FDCA esters, proceeds without formation of levulinic acid or insoluble humins. This new route provides an attractive strategy to valorize agricultural waste streams and a route to furanic building blocks without the co-production of levulinic acid or humins.

SUBSTITUTED AMIDE COMPOUND

A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.

A new synthesis of 8-oxabicyclo[3.2.1]octan-2-one and its use for the preparation of cycloheptane annulated furans

Two novel syntheses of 8-oxabicyclo[3.2.1]octan-2-one are described, making this key intermediate readily available in preparative amounts. On chain elongation with various oxophosphonates this compound is converted to α,β-unsaturated ketones, which, on t

Heterocyclic indole derivatives and mono- or diazaindole derivatives

There is provided a compound represented by the general formula (1): wherein Het represents an optionally substituted heterocyclic group; A1and A2each independently represent —CH═, etc.; A3represents —CH2—, etc.; R1represents a 4-fluorophenyl group, etc.; R2represents an alkyl group; n represents 0, 1 or 2, provided that when A1and A2both are —CH═, A3represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.

HETEROCYCLIC INDOLE DERIVATIVES AND MONO- OR DIAZAINDOLE DERIVATIVES

Indole derivatives and mono- or diazaindole derivatives represented by general formula (1), pharmaceutically acceptable acid-addition salts or base-addition salts thereof or hydrates of the same which have a COX-2 inhibitory activity and are useful as drugs such as anti-inflammatory agents, wherein Het represents an optionally substituted heterocycle; A1 and A2 independently represent each -CH=, etc.; A3 represents -CH2-, etc.; R1 represents 4-fluorophenyl, etc.; R2 represents alkyl; and n is 0, 1 or 2, provided that when A1 and A2 are both -CH=, then A3 is -CH2- or -SO2-.

Reaction of ethyl ester and nitrile of 5-methyl-2-furancarboxylic acid with mixture of nitric and sulfuric acids

The reaction of 70% HNO3 with ethyl 5-methyl-2- furancarboxylate in concentrated H2SO4 gave the corresponding 4-nitro derivative and ethyl 5-formyl-2-furancarboxylate. Only 4-nitro derivative, which was converted into amid

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.