225520-10-5Relevant academic research and scientific papers
Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents
Cai, Jin,Sun, Min,Wu, Xiaoqing,Chen, Junqing,Wang, Peng,Zong, Xi,Ji, Min
, p. 702 - 712 (2013/07/27)
Three series of novel 4-benzothiazole amino quinazolines Dasatinib derivatives have been designed and synthesized. The entire target compounds were investigated for their in vitro cytotoxic activity by the MTT-based assay against 6 human cancer cell lines
Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117
Das, Jagabandhu,Lin, James,Moquin, Robert V.,Shen, Zhongqi,Spergel, Steven H.,Wityak, John,Doweyko, Arthur M.,DeFex, Henry F.,Fang, Qiong,Pang, Suhong,Pitt, Sidney,Shen, Ding Ren,Schieven, Gary L.,Barrish, Joel C.
, p. 2145 - 2149 (2007/10/03)
A series of structurally novel benzothiazole based small molecule inhibitors of p56lck were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in the T-cell proliferation assay. BMS-243117 (compound 2) is identified as a potent, and selective Lck inhibitor with good cellular activity (IC50=1.1 μM) against T-cell proliferation.
Benzothiazole protein trosine kinase inhibitors
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, (2008/06/13)
Novel benzothiazoles and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
