225641-84-9

Basic information

• Product Name: Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI);(3-Hydroxy-cyclopentyl)-carbamic acid tert-butyl ester;[(1R,3S)-3-Hydroxycyclopentyl]carbamic acid tert-butyl ester;tert-butyl (1S,3R)-3-hydroxycyclopentylcarbamate;tert-Butyl ((1R,3S)-3-hydroxycyclopentyl)carbaMate;Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester;tert-butyl N-[(1R,3S)-3-hydroxycyclopentyl]carbamate;tert-Butyl ((1R,3S)
• CAS NO: 225641-84-9
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26276
• Product Categories: N-BOC
• Mol File: 225641-84-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 320.8 °C at 760 mmHg
• Flash Point: 147.8 °C
• Appearance: /
• Density: 1.08g/cm³
• Storage Temp.: 2-8°C
• PKA: 12.27±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)(225641-84-9)
• EPA Substance Registry System: Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)(225641-84-9)

Safety Data

• Hazardous Substances Data: 225641-84-9(Hazardous Substances Data)

Usage

Uses

Carbamic acid, [(1R,3S)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) is carboxylic acid ester organic compounds, which can be used as pharmaceutical intermediates.

Upstream product

• 108-05-4 vinyl acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1036260-18-0 (1S,3R)-3-aminocyclopentane-1-ol 
• 99027-90-4 2-oxa-3-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acidtert-butyl ester 
• 201054-55-9 (+)-(1R,4S)-1-hydroxy-4-[(tert-butoxycarbonyl)amino]-2-cyclopentene 

Downstream Products

• 225641-86-1 tert-butyl (R)-(3-oxocyclopentyl)carbamate 
• 124555-33-5 (1S,3R)-3-aminocyclopentan-1-ol hydrochloride 
• 225641-88-3 [(1R,3S)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentyl]-carbamic acid tert-butyl ester 
• 225641-89-4 [(1R,3R)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentyl]-carbamic acid tert-butyl ester 
• 754963-28-5 1-((1S,3R)-3-Amino-cyclopentyl)-4-phenyl-piperidine-4-carbonitrile 

Relevant articles and documents

POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS

Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective α(1a)-receptor

Several 1,3-diaminocyclopentane linked α(1a)-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on α1-receptor binding. (C) 2000 Published by Elsevier Science Ltd.