225642-66-0

Upstream product

• 558459-44-2 [2-((2S,3S,8R,9S)-8-benzyloxy-3-chloro-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-2-yl)-ethoxy]-tert-butyl-diphenyl-silane 
• 558459-28-2 (3S,4R)-4-benzyloxy-hept-6-en-3-ol 
• 558459-29-3 [(1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy]-acetic acid 
• 558459-36-2 2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-(2S)-5-methyl-hex-4-en-1-ol 
• 558459-42-0 (2S,3R,8R,9S)-8-benzyloxy-9-ethyl-2-(2-hydroxy-ethyl)-2,3,4,7,8,9-hexahydro-oxonin-3-ol 
• 558459-26-0 3-[2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-acetyl]-4-isopropyl-oxazolidin-2-one 
• 558459-37-3 5-[(1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy]-(4R,5S)-8-methyl-nona-1,7-dien-4-ol 
• 558459-35-1 3-[2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-(2S)-5-methyl-hex-4-enoyl]-(4R)-4-isopropyl-oxazolidin-2-one 
• 225642-87-5 (Z)-(3S,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-9-[1,3]dithian-2-yl-non-6-en-3-ol 
• 225642-89-7 (Z)-(7S,8S)-10-(tert-Butyl-diphenyl-silanyloxy)-7-chloro-8-hydroxy-dec-4-enoic acid 
• 225642-70-6 tert-Butyl-[2-((5Z,8Z)-(2S,3S)-3-chloro-9-ethyl-2,3,4,7-tetrahydro-oxonin-2-yl)-ethoxy]-diphenyl-silane 
• 225642-73-9 9-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8-chloro-4,7,8,9-tetrahydro-3H-oxonin-2-one 
• 225642-75-1 (3R,4R)-1-(tert-Butyl-dimethyl-silanyloxy)-3-chloro-9-[1,3]dioxolan-2-yl-non-6-yn-4-ol 
• 225642-77-3 (Z)-(3R,4R)-1-(tert-Butyl-dimethyl-silanyloxy)-3-chloro-9-[1,3]dioxolan-2-yl-non-6-en-4-ol 

Downstream Products

• 71939-43-0 (+)-obtusenyne 
• 225642-64-8 [(2S,3S,8S,9S)-2-(8-bromo-3-chloro-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-2-yl)-ethoxy]-tert-butyl-diphenyl-silane 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-obtusenyne

A total synthesis of the laurencia metabolite (+)-obtusenyne has been completed. The key steps include a Sharpless kinetic resolution and an asymmetric glycolate alkylation to establish the stereogenic centers adjacent to the ether linkage and a ring-clos

Determination of the absolute configurations of norte's obtusenynes by total syntheses of (12R,13R)-(-)- and (12S,13R)-(+)-obtusenynes

The total syntheses of (12R,13R)-(-)-obtusenynes and (12S,13R)-(+)-obtusenynes were achieved. The absolute configurations of the obtusenynes isolated by Norte from Laurencia pinnatifida were clarified as the former.