558459-44-2

Upstream product

• 558459-43-1 (2S,3R,8R,9S)-8-benzyloxy-2-[2-(tert-butyl-diphenyl-silanyloxy)ethyl]-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-3-ol 
• 99838-72-9 (2S)-2-[(1R)-1-benzyloxy-but-3-enyl]-oxirane 
• 558459-28-2 (3S,4R)-4-benzyloxy-hept-6-en-3-ol 
• 558459-29-3 [(1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy]-acetic acid 
• 558459-55-5 2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-(2S)-5-methyl-hex-4-enal 
• 558459-36-2 2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-(2S)-5-methyl-hex-4-en-1-ol 
• 558459-42-0 (2S,3R,8R,9S)-8-benzyloxy-9-ethyl-2-(2-hydroxy-ethyl)-2,3,4,7,8,9-hexahydro-oxonin-3-ol 
• 558459-26-0 3-[2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-acetyl]-4-isopropyl-oxazolidin-2-one 
• 558459-37-3 5-[(1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy]-(4R,5S)-8-methyl-nona-1,7-dien-4-ol 
• 558459-58-8 [(2S,3R,8R,9S)-8-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-acetaldehyde 
• 558459-41-9 [(2S,3R,8R,9S)-8-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-ethanol 
• 558459-46-4 1-[(2S,3R,8R,9S)-3-(tert-butyldimethyl-silanyloxy)-9-ethyl-8-benzyloxy-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-3-methylbutane-2,3-diol 
• 558459-39-5 {(1R)-1-[(1S)-1-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-2-(3,3-dimethyloxiranyl)-ethyl]-but-3-enyloxy}-tert-butyl-dimethyl-silane 
• 558459-25-9 [(1R,2S)-1-allyl-2-((1S,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-5-methyl-hex-4-enyloxy]-tert-butyl-dimethyl-silane 

Downstream Products

• 225642-64-8 [(2S,3S,8S,9S)-2-(8-bromo-3-chloro-9-ethyl-2,3,4,7,8,9-hexahydro-oxonin-2-yl)-ethoxy]-tert-butyl-diphenyl-silane 
• 71939-43-0 (+)-obtusenyne 
• 225642-66-0 (2S,3R,8S,9S)-9-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8-chloro-2-ethyl-2,3,4,7,8,9-hexahydro-oxonin-3-ol 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-obtusenyne

A total synthesis of the laurencia metabolite (+)-obtusenyne has been completed. The key steps include a Sharpless kinetic resolution and an asymmetric glycolate alkylation to establish the stereogenic centers adjacent to the ether linkage and a ring-clos