225655-77-6

Upstream product

• 213194-48-0 (1E,4E)-7-(tert-butyldiphenylsilyloxy)-2,4-dimethyl-1-iodohepta-1,4-diene 
• 13857-47-1 (E)-4-methylhept-3-en-6-yn-1-ol 
• 213195-53-0 tert-butyl-(7,7-dibromo-3-methyl-hept-6-enyloxy)-dimethyl-silane 
• 213194-57-1 (3S)-1-[(tert-butyldimethylsilyl)oxy]-3-methylhept-6-yne 
• 213195-62-1 (E)-7-(tert-butyldiphenylsilyloxy)-4-methylhept-4-en-1-yne 
• 13700-37-3 (E)-7-Bromo-4-methyl-hept-4-en-1-yne 
• 6712-34-1 2-cyclopropylpent-4-yn-2-ol 
• 13927-59-8 (E)-7-acetoxy-4-methylhept-4-en-1-yne 

Downstream Products

• 444989-34-8 (4R)-3-[(2R,3S,5E,8E,10E,14S)-15-allyloxycarbonylamino-3-(1-ethoxyethoxy)-2,6,8,14-tetramethylpentadeca-5,8,10-trienoyl]-4-benzyloxazolidin-2-one 
• 444989-33-7 (4R)-3-[(2R,3S,5E,8E,10E,14S)-15-allyloxycarbonylamino-3-hydroxy-2,6,8,14-tetramethylpentadeca-5,8,10-trienoyl]-4-benzyloxazolidin-2-one 
• 444989-32-6 (3S,6E,8E,12S)-13-allyloxycarbonylamino-1-tert-butyldiphenylsilyloxy-4,6,12-trimethyltrideca-3,6,8-triene 
• 444989-31-5 (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trienoic acid 
• 444989-30-4 (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trien-al 
• 444989-29-1 (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trien-1-ol 

Relevant academic research and scientific papers

Enantioselective total synthesis of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

Enantioselective total synthesis of an antitumor antibiotic, vicenistatin, featuring a 20-membered macrocyclic lactam glycoside with the amino sugar vicenisamine, has been achieved. Key reactions in the synthesis of macrolactam aglycone involved Suzuki cross-coupling and Evans asymmetric aldol reaction. Penultimate glycosidation of the O-TMS-aglycone with appropriately protected 1-O-acetyl amino sugar and final deprotection allowed accomplishment of the total synthesis.