6712-34-1

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 106-96-7 propargyl bromide 

Downstream Products

• 213194-85-5 (2E,4E,9E,12E,14E)-(6S,7S,18S)-7-(1-Ethoxy-ethoxy)-19-[(4-methoxy-benzyl)-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-6,10,12,18-tetramethyl-nonadeca-2,4,9,12,14-pentaenoic acid 2-trimethylsilanyl-ethyl ester 
• 213195-40-5 [(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 213194-72-0 [(5E,7E,10E)-(2S,13S,14R)-13-Hydroxy-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 213194-79-7 [(5E,7E,10E)-(2S,13S,14S)-13-(1-Ethoxy-ethoxy)-15-hydroxy-2,8,10,14-tetramethyl-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 213195-44-9 [(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 213195-48-3 (2E,4E,9E,12E,14E)-(6S,7S,18S)-7-(1-Ethoxy-ethoxy)-19-(4-methoxy-benzylamino)-6,10,12,18-tetramethyl-nonadeca-2,4,9,12,14-pentaenoic acid 
• 213194-92-4 (3E,5E,10E,13E,15E)-(7S,8S,19S)-8-(1-Ethoxy-ethoxy)-1-(4-methoxy-benzyl)-7,11,13,19-tetramethyl-azacycloicosa-3,5,10,13,15-pentaen-2-one 
• 213194-66-2 ((5E,7E,10E)-(S)-13-Hydroxy-2,8,10-trimethyl-trideca-5,7,10-trienyl)-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 213195-33-6 (4-Methoxy-benzyl)-((5E,7E,10E)-(S)-2,8,10-trimethyl-13-oxo-trideca-5,7,10-trienyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 444989-34-8 (4R)-3-[(2R,3S,5E,8E,10E,14S)-15-allyloxycarbonylamino-3-(1-ethoxyethoxy)-2,6,8,14-tetramethylpentadeca-5,8,10-trienoyl]-4-benzyloxazolidin-2-one 
• 444989-33-7 (4R)-3-[(2R,3S,5E,8E,10E,14S)-15-allyloxycarbonylamino-3-hydroxy-2,6,8,14-tetramethylpentadeca-5,8,10-trienoyl]-4-benzyloxazolidin-2-one 
• 225655-77-6 (3E,6E,8E,12S)-14-tert-butyldimethylsilyloxy-1-tert-butyldiphenylsilyloxy-4,6,12-trimethyltetradeca-3,6,8-triene 
• 444989-32-6 (3S,6E,8E,12S)-13-allyloxycarbonylamino-1-tert-butyldiphenylsilyloxy-4,6,12-trimethyltrideca-3,6,8-triene 
• 444989-31-5 (3S,6E,8E,11E)-14-tert-butyldiphenylsilyloxy-3,9,11-trimethyltetradeca-6,8,11-trienoic acid 

Relevant academic research and scientific papers

Enantioselective total synthesis of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

Enantioselective total synthesis of an antitumor antibiotic, vicenistatin, featuring a 20-membered macrocyclic lactam glycoside with the amino sugar vicenisamine, has been achieved. Key reactions in the synthesis of macrolactam aglycone involved Suzuki cross-coupling and Evans asymmetric aldol reaction. Penultimate glycosidation of the O-TMS-aglycone with appropriately protected 1-O-acetyl amino sugar and final deprotection allowed accomplishment of the total synthesis.