625-75-2

Basic information

• Product Name: ALFA-NITRO ACETIC ACID
• Synonyms: ALFA-NITRO ACETIC ACID;nitroacetic acid;ALPHA-NITROACETIC ACID;2-Nitroacetic acid;2-nitroethanoic acid;Dipotassium 2-nitroacetate
• CAS NO: 625-75-2
• Molecular Formula: C₂H₃NO₄
• Molecular Weight: 105.05
• Mol File: 625-75-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 87-89 °C
• Boiling Point: 297.9°C at 760 mmHg
• Flash Point: 150.6°C
• Appearance: /
• Density: 1.523g/cm³
• Vapor Pressure: 0.000314mmHg at 25°C
• Refractive Index: 1.46
• PKA: 1.48(at 24℃)
• CAS DataBase Reference: ALFA-NITRO ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ALFA-NITRO ACETIC ACID(625-75-2)
• EPA Substance Registry System: ALFA-NITRO ACETIC ACID(625-75-2)

Safety Data

• Hazardous Substances Data: 625-75-2(Hazardous Substances Data)

Usage

Physical state

Pale yellow solid

Solubility

Soluble in water

Main use

Precursor to various other chemical compounds in organic synthesis

Derivative of

Acetic acid

Primary applications

Production of pharmaceuticals and agrochemicals

Other uses

Reagent for synthesis of organic compounds, building block for chemical products

Hazard level

Considered moderate hazard, caution required for handling

Importance

Wide range of applications in chemical industry, important intermediate in synthesis of various compounds

InChI:InChI=1/C2H3NO4/c4-2(5)1-3(6)7/h1H2,(H,4,5)

Upstream product

• 73506-45-3 potassium nitroacetate 
• 75-52-5 nitromethane 
• 68-12-2 N,N-dimethyl-formamide 
• 124-38-9 carbon dioxide 

Downstream Products

• 2562-42-7 1-nitromethylcyclopentene 
• 22568-49-6 (E)-1-(4-hydroxyphenyl)-2-nitroethene 
• 22568-51-0 (E)-2-methoxy-4-(2-nitrovinyl)phenol 
• 3156-39-6 (E)-1-nitro-2-(2-nitrovinyl)benzene 
• 117636-87-0 Nitroessigsaeure(-)menthylester 
• 5330-61-0 1-nitromethyl-cyclohexene 
• 22568-50-9 4-(2-Nitrovinyl)benzoic acid methyl ester 
• 117123-45-2 oxalic acid-1-chloride-2-cyclohexyl ester-1-oxime 
• 56161-87-6 nitro-acetic acid cyclohexyl ester 
• 30563-27-0 benzyl 2-nitroacetate 
• 144-62-7 oxalic acid 
• 75-52-5 nitromethane 
• 15719-64-9 methylammonium carbonate 
• 626-35-7 nitroacetic acid ethyl ester 

Relevant articles and documents

Mechanistic rationalization of unusual sigmoidal kinetic profiles in the machetti-de sarlo cycloaddition reaction

Unusual sigmoidal kinetic profiles in the Machetti-De Sarlo base-catalyzed 1,3-dipolar cycloaddition of acrylamide to N-methylnitroacetamide are rationalized by detailed in situ kinetic analysis. A dual role is uncovered in which a substrate acts as a precursor to catalyze its own reaction. Such kinetic studies provide a general protocol for distinguishing among different mechanistic origins of induction periods in complex organic reactions.

Formal synthesis of belactosin A and hormaomycin via a diastereoselective intramolecular cyclopropanation of an α-nitro diazoester

Chemical Equation presented An efficient and convenient methodology for the synthesis of the 3-(trans-2-aminocyclopropyl) alanine and 3-(trans-2- nitrocyclopropyl) alanine moieties found In the core of belactosln A and hormaomycin, respectively, Is reported. By using an enantioenriched substituted α-nitro diazoester In a diastereoselective Intramolecular cyclopropanatlon reaction, the trans-nitrocyclopropyl alanine moiety can be obtained efficiently In five steps from the Initial α-nitrocyclopropyl lactone unit, thus achieving the synthesis of the cyclopropane core of the two natural products.