22573-54-2

Upstream product

• 124-38-9 carbon dioxide 
• 23406-61-3 (-)-(R)-1-Chlor-2-phenyl-3-methyl-butan 
• 621-82-9 Cinnamic acid 
• 126275-15-8 4-methyl-3-phenylpentanoyl chloride 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 
• 51690-50-7 4-methyl-3-phenylpentanoic acid 
• 1015083-84-7 C₁₇H₁₉NO 
• 13491-13-9 (R)-2-isopropyl-2-phenylacetic acid 
• 100-58-3 phenylmagnesium bromide 
• 102-92-1 Cinnamoyl chloride 
• 857637-83-3 (E)-(4S,5R)-4-benzyl-3-(3'-phenyl-2'-propenoyl)-5-(1'H,1'H,2'H,2'H-perfluorooctyl)-2-oxazolidinone 
• 75-30-9 2-iodo-propane 
• 63677-96-3 (E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one 
• 857637-86-6 (3'R,4S,5R)-4-benzyl-3-(4'-methyl-3'-phenyl-pentanoyl)-5-(1'H,1'H,2'H,2'H-perfluorooctyl)-2-oxazolidinone 

Downstream Products

• 1462940-79-9 (S)-2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 4-methyl-3-phenylpentanoate 
• 1462940-81-3 (S)-2,3,5,6-tetrafluoro-4-methylbenzyl 4-methyl-3-phenylpentanoate 
• 1462940-74-4 (R)-2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 4-methyl-3-phenylpentanoate 
• 1462940-80-2 (R)-2,3,5,6-tetrafluoro-4-methylbenzyl 4-methyl-3-phenylpentanoate 

Relevant academic research and scientific papers

Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst

Evaluation of an esterase annotated as 26D isolated from a marine metagenomic library is described. Esterase 26D was found to have a unique substrate scope, including synthetic transformations which could not be readily effected in a synthetically useful manner using commercially available enzymes. Esterase 26D was more selective towards substrates which had larger, more sterically demanding substituents (i. e. iso-propyl or tert-butyl groups) on the β-carbon, which is in contrast to previously tested commercially available enzymes which displayed a preference for substrates with sterically less demanding substituents (e.g. methyl group) at the β-carbon. (Figure presented.).

Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol

A series of novel chiral esters derived from tetrafluorobenzyl alcohol were designed and prepared via asymmetric synthesis. The target molecules have been identified on the basis of analytical spectra data. All newly synthesized compounds have been screened their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and d-trans-phenothrin by standard method, and the respective pairs of enantiomers (3-B1-R/S, 3-C1-R/S, 3-D1-R/S) indicated significantly different activities.

Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol

A series of novel chiral esters derived from tetrafluorobenzyl alcohol were designed and prepared via asymmetric synthesis. The target molecules have been identified on the basis of analytical spectra data. All newly synthesized compounds have been screened their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and d-trans-phenothrin by standard method, and the respective pairs of enantiomers (3-B1-R/S, 3-C1-R/S, 3-D1-R/S) indicated significantly different activities.

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

Chiral Lewis acid catalyzed enantioselective conjugate radical additions to α,β-unsaturated 2-pyridyl ketones

We have investigated the utility of a pyridine-based achiral template in enantioselective conjugate radical additions. Georg Thieme Verlag Stuttgart.

Enantioselective conjugate radical addition to α′-hydroxy enones

(Chemical Equation Presented) Enantioselective conjugate radical addition to α′-hydroxy α,β-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to α′-hydroxy α,β-unsaturated ketones i

Stereoselective conjugate radical additions: Application of a fluorous oxazolidinone chiral auxiliary for efficient tin removal

(Chemical Equation Presented) A series of asymmetric free-radical-mediated intermolecular conjugate additions using a fluorous oxazolidinone chiral auxiliary has been completed. The fluorous auxiliary facilitated product isolation using fluorous solid phase extractions (FSPE), effectively removing excess organic and organometallic reagents. Parallel reactions carried out with a similar but nonfluorous norephedrine-derived oxazolidinone demonstrated the superior stereoselectivity and purification obtainable with the fluorous chiral auxiliary.

Enantioselective intermolecular free radical conjugate additions. Application of a pyrazole template

An achiral pyrazole template has been evaluated in enantioselective conjugate radical additions. The enantioselectivity using the pyrazole template is inferior to those obtained from an oxazolidinone template. The two templates give products of opposite c

Preparation of chiral indanones and dihydrocoumarins; Application to synthesis of (+)-3-(2,6-dimethoxyphenyl) pentanoic acid

Chiral β-aryl carboxylic acids, prepared by Michael addition of organocuprates to chiral unsaturated imides, are transformed into chiral 3- alkyl-4-benzoyloxyindan-1-ones via two intramolecular acylations, with intermediate formation of chiral 3-alkylindanones and corresponding dihydrocoumarins. The 3-(S)-ethyl-4-benzoyloxyindanone is transformed into(+)-3-(S)-(2,6-dimethoxyphenyl)pentanoic acid.