225786-63-0

Upstream product

• 225786-60-7 5-(hexyloxy)-2-nitrobenzaldehyde 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 111-25-1 1-bromo-hexane 
• 60463-12-9 3-hydroxymethyl-4-nitrophenol 

Downstream Products

• 1296753-07-5 C₁₅H₂₀N₄O₅ 

Relevant academic research and scientific papers

Light-Responsive, Shape-Switchable Block Copolymer Particles

A robust strategy is developed for preparing light-responsive block copolymer (BCP) particles in which shape and color can be actively controlled with high spatial and temporal resolution. The key to achieving light-responsive shape transitions of BCP par

Near-infrared light-sensitive liposomes for controlled release

A photoresponsive amphiphilic lipid molecule with phosphatidylcholine as the headgroup and a near-infrared (NIR) light-responsive unit on the hydrophobic moiety was synthesized. Liposomes constituting the NIR-responsive lipid, cholesterol and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, were constructed and applied as a photocontrolled release system. The precisely controlled release of the loaded cargo was demonstrated by adjusting the irradiation parameters and content of the photoresponsive species. The low cytotoxicity and good biocompatibility of the photoresponsive lipid was demonstrated by MTT assay. This study provides us with a new choice for developing a photoresponsive drug delivery system.

Photosensitivity carboxylic acid polymer, in the preparation and application of drug release

The invention relates to a preparation method for a carboxylic acid molecule, specifically to a photosensitive carboxylic acid molecule, and a preparation method and application thereof. According to the invention, 5-hydroxyl-nitrobenzaldehyde is used as a starting material to prepare o-nitrobenzyl-containing fatty acid through simple unit synthesis; light-degradable-unit-containing carboxylic acid is prepared through simple standard organic unit reactions like etherification, reduction and esterification; meanwhile, the method in the invention uses cheap raw materials and has simple synthetic process, so the photosensitive carboxylic acid molecule with different structures can be prepared with low cost; and an obtained target product can reach a level of hectogram and realize the purity of more than 98% through simple crystallization. In addition, the invention also discloses the application of the photosensitive carboxylic acid molecule in drug sustained release; meanwhile, drug-loading and photocontrolled release capacities of photosensitive phospholipid vesicles synthesized from light-degradable carboxylic acid prove that the photosensitive carboxylic acid molecule has good photoresponse performance.

Photoregulated release of noncovalent guests from dendritic amphiphilic nanocontainers

Supramolecular disassembly: Phototriggered release of noncovalently sequestered lipophilic guest molecules from dendritic supramolecular assemblies has been demonstrated. Facially amphiphilic dendrimers have been shown to provide a unique opportunity to f