60463-12-9

Usage

Uses

Used in Chemical Synthesis:
5-HYDROXY-2-NITROBENZYL ALCOHOL is used as a key intermediate in the synthesis of various organic compounds. Its hydroxyl and nitro groups can be further modified or reacted with other molecules to produce a wide range of products.
Used in Pharmaceutical Applications:
5-HYDROXY-2-NITROBENZYL ALCOHOL is used as a starting material for the development of new pharmaceutical compounds. Its unique structure and functional groups can be exploited to design and synthesize novel drugs with potential therapeutic applications.
Used in Polymer Science:
5-HYDROXY-2-NITROBENZYL ALCOHOL is used as a difunctional photo-responsive initiator in the synthesis of thermo-responsive and photo-cleavable amphiphilic block copolymers. These copolymers contain photodegradable linkers as junction points between hydrophilic and hydrophobic chains, which can be utilized in various applications such as drug delivery systems, self-assembling materials, and stimuli-responsive materials.
Used in the Synthesis of 5-(2′-(DIMETHYLAMINO)ETHOXY)-2-NITROBENZYL ALCOHOL:
5-HYDROXY-2-NITROBENZYL ALCOHOL is used as a precursor in the synthesis of 5-(2′-(dimethylamino)ethoxy)-2-nitrobenzyl alcohol. This derivative can be employed in various applications, such as photochemical reactions and the development of new materials with unique properties.

InChI:InChI=1/C7H7NO4/c9-4-5-3-6(10)1-2-7(5)8(11)12/h1-3,9-10H,4H2

Upstream product

• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 

Downstream Products

• 161009-59-2 5-((2-methoxy)ethoxymethoxy)-2-nitrophenylmethanol 
• 233281-74-8 tert-butyl 4-[(3-hydroxymethyl-4-nitro)phenoxy]piperidine-1-carboxylate 
• 495400-11-8 Acetic acid (2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-2-(5-hydroxy-2-nitro-benzyloxy)-5-((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yl ester 
• 872578-78-4 (5-(3-azidopropoxy)-2-nitrophenyl)methanol 
• 177275-28-4 2-nitro-5-(2-quinolylmethoxy)benzyl alcohol 
• 189359-78-2 2-Nitro-5-(2-propyloxy)benzyl alcohol 
• 225786-63-0 5-hexyloxy-2-nitrobenzyl alcohol 
• 744992-67-4 5-(2-(dimethylamino)ethoxy)-2-nitrobenzyl alcohol 
• 161009-71-8 (S)-3-[2-tert-Butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyloxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid methyl ester 
• 161009-69-4 (S)-3-[2-tert-Butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyloxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 
• 161009-65-0 (S)-3-[2-tert-Butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 161009-63-8 (S)-3-[5-(2-Methoxy-ethoxymethoxy)-2-nitro-benzyloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 161009-67-2 (S)-2-Amino-3-[2-tert-butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyloxy]-propionic acid methyl ester 
• 161009-61-6 2-Iodomethyl-4-(2-methoxy-ethoxymethoxy)-1-nitro-benzene 

Relevant academic research and scientific papers

Synthesis of photocleavable poly(methyl methacrylate-block- d -lactide) via atom-transfer radical polymerization and ring-opening polymerization

The synthesis and characterization of a photocleavable block copolymer containing an ortho-nitrobenzyl (ONB) linker between poly(methyl methacrylate) and poly(d-lactide) blocks is presented here. The block copolymers were synthesized via atom transfer rad

Stimuli-responsive lipidic cubic phase: Triggered release and sequestration of guest molecules

New stimuli-responsive nanomaterials, made up of host-guest lipidic cubic phases (LCPs) are presented. These biocompatible, stable, transparent and water-insoluble LCPs are composed of monoolein (MO) as a neutral host, and small amounts of one of three ju

Preparation and application of a dual light-responsive triblock terpolymer

Reported are the preparation and application of a triblock terpolymer poly(ethylene oxide)-ONB-poly[2-(perfluorooctyl)ethyl methacrylate]-block- poly(2-cinnamoyloxyethyl methacrylate) (PEO-ONB-PFOEMA-b-PCEMA). Here PEO is water-soluble, PCEMA is photo-cro

Protein Spin Labeling with a Photocaged Nitroxide Using Diels–Alder Chemistry

EPR spectroscopy of diamagnetic bio-macromolecules is based on site-directed spin labeling (SDSL). Herein, a novel labeling strategy for proteins is presented. A nitroxide-based spin label has been developed and synthesized that can be ligated to proteins

Synthesis of Photo, Oxidative, and Reductive Triple-Stimuli-Responsive Block Copolymer Micelles as Nanocarriers for Controlled Release

With the rapid development of nanotechnology, stimuli-responsive nanomaterials have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. The environment of the human body is comple

Photo- and pH-Responsive Polycarbonate Block Copolymer Prodrug Nanomicelles for Controlled Release of Doxorubicin

Photo/pH dual-responsive amphiphilic diblock copolymers with alkyne functionalized pendant o-nitrobenzyl ester group are synthesized using poly(ethylene glycol) as a macroinitiator. The pendant alkynes are functionalized as aldehyde groups by the azide-al

Light-Responsive, Shape-Switchable Block Copolymer Particles

A robust strategy is developed for preparing light-responsive block copolymer (BCP) particles in which shape and color can be actively controlled with high spatial and temporal resolution. The key to achieving light-responsive shape transitions of BCP par

Precise surface structure of nanofibres with nearly atomic-level precision

We report the first example of endowing the surface structure of a polymeric assembly with nearly atomic-level precision. The solenoidal wrapping of a DNA chain around the surface of a nanofibre transcribes the precise sequence structure of the DNA onto t

Arrays with cleavable linkers

The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.

Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array

Sweet and light: Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one-pot strategy to synthesize the tumor-associated carbohydrate antigen N3 minor (1). The target molecule was attached covalently to a porous silicon surface through a photocleavable linker for direct characterization in a mass spectrometer equipped with a laser source. (Chemical Equation Presented).