2258-73-3Relevant academic research and scientific papers
Reaction of oximes of-diketones with diphosphorous tetraiodide for preparation of oxadiazoles and nitriles
Telvekar, Vikas N.,Takale, Balaram S.
, p. 221 - 227,7 (2020/09/02)
The utility of diphosphorous tetraiodide as a new, mild, condensing agent for synthesis of oxadiazole is described. These data indicate the simple dehydration of oximes to 1,2,5-oxadiazole as well as the rearrangements of oximes to normal Beckmann product 1,2,4-oxadiazole. However, mono-oxime of benzil undergoes abnormal Beckman rearrangement to benzaldehyde as major product. The described method is simple and important for the synthesis of the oxadiazoles as well as for nitriles.
