22591-41-9

Upstream product

• 94633-26-8 ethyl 5,5,5-trifluoro-4-tosyloxyvalerate 
• 70961-06-7 ethyl 4-hydroxy-5,5,5-trifluoropentanoate 
• 22581-33-5 (±)-trans-2-(trifluoromethyl)cyclopropane-1-carboxylic acid 
• 94633-25-7 ethyl 5,5,5-trifluoro-4-oxo-3-ethoxycarbonyl-pentanoate 
• 70961-05-6 4-trifluoromethyl-4-oxobutyric acid ethyl ester 
• 22666-34-8 trans-2-trifluoromethylcyclopropylmethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Regioselectivity in the Ring Opening of 2-Alkylcyclopropylmethyl Radicals: the Effect of Electronegative Substituents

The regioselectivity of the ring-opening of the trans-2-alkylcyclopropylmethyl radical A to give the primary alkyl radicals B, or the secondary alkyl radicals C, has been investigated, where the groups R and/or CXY carry electronegative substituents.All these reactions gave principally the secondary alkyl radicals C, whereas, in the absence of electronegative substituents, ring-opening occurs in favour of the primary alkyl radicals B.This regioselectivity is interpreted in terms of the frontier orbital interactions which are involved.