22581-33-5

Basic information

• Product Name: 2-(trifluoroMethyl)cyclopropanecarboxylic acid
• Synonyms: 2-(trifluoroMethyl)cyclopropanecarboxylic acid;2-(trifluoromethyl)cyclopropane-1-carboxylic acid
• CAS NO: 22581-33-5
• Molecular Formula: C₅H₅F₃O₂
• Molecular Weight: 154.0872096
• Mol File: 22581-33-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 168.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.563±0.06 g/cm3(Predicted)
• PKA: 3.95±0.11(Predicted)
• CAS DataBase Reference: 2-(trifluoroMethyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trifluoroMethyl)cyclopropanecarboxylic acid(22581-33-5)
• EPA Substance Registry System: 2-(trifluoroMethyl)cyclopropanecarboxylic acid(22581-33-5)

Safety Data

• Hazardous Substances Data: 22581-33-5(Hazardous Substances Data)

Usage

General Description

2-(trifluoroMethyl)cyclopropanecarboxylic acid is a chemical compound with the molecular formula C5H5F3O2. It is a cyclopropane derivative that contains a trifluoromethyl group and a carboxylic acid functional group. 2-(trifluoroMethyl)cyclopropanecarboxylic acid is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and other organic compounds. It is known for its unique chemical reactivity and ability to participate in a variety of organic reactions, making it a valuable tool for organic chemists. Additionally, it has potential applications in agrochemicals and materials science due to its structural and functional properties.

Upstream product

• 70961-06-7 ethyl 4-hydroxy-5,5,5-trifluoropentanoate 
• 94633-25-7 ethyl 5,5,5-trifluoro-4-oxo-3-ethoxycarbonyl-pentanoate 
• 70961-05-6 4-trifluoromethyl-4-oxobutyric acid ethyl ester 
• 94633-26-8 ethyl 5,5,5-trifluoro-4-tosyloxyvalerate 
• 22581-31-3 methyl 5,5,5-trifluoro-4-oxopentanoate 
• 22581-28-8 methyl 5,5,5-trifluoro-4-hydroxypentanoate 
• 684-76-4 5,5,5-trifluoro-4-oxopentanoic acid 
• 22581-32-4 5,5,5-Trifluor-4-(p-toluolsulfonyloxy)-valeriansaeure-methylester 

Downstream Products

• 22591-41-9 Toluene-4-sulfonic acid (1R,2R)-2-trifluoromethyl-cyclopropylmethyl ester 
• 22666-34-8 trans-2-trifluoromethylcyclopropylmethanol 

Relevant articles and documents

Iron-catalyzed preparation of trifluoromethyl substituted vinyl- and alkynylcyclopropanes

A convenient iron-catalyzed procedure to prepare trifluoromethylated vinyl- and alkynylcyclopropanes in a chemo- and diastereoselective manner is presented. The active diazo compound (trifluoromethyl diazomethane) is generated in situ and used in the conc

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

Piperazine derivatives and their use as therapeutic agents

Compounds for treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the compounds are of formula (I): where x y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.