225930-54-1Relevant articles and documents
Synthesis and structure - Activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors
Ishibuchi, Seigo,Morimoto, Hiroshi,Oe, Takanori,Ikebe, Tsuguo,Inoue, Hiroyoshi,Fukunari, Atsushi,Kamezawa, Miho,Yamada, Ichimaro,Naka, Yoichi
, p. 879 - 882 (2001)
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.