138907-80-9

Usage

Uses

Used in Pharmaceutical Research:
1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid is used as a chemical intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the creation of novel drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid serves as a key building block for synthesizing complex organic molecules. Its reactivity and functional groups enable the formation of a wide range of chemical products with diverse applications.
Used in Material Science:
1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid may also find applications in material science, where its unique properties could be utilized in the development of new materials with specific characteristics, such as improved stability or enhanced reactivity.
Used in Analytical Chemistry:
1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid can be employed as a reference material or standard in analytical chemistry for the calibration of instruments and the development of new analytical methods, given its distinct chemical and physical properties.

Upstream product

• 110821-33-5 ethyl 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 225930-54-1 3-amino-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 63874-99-7 1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 25419-86-7 1-(4-chlorophenyl)-1H-pyrazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 14678-87-6 ethyl 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate 

Downstream Products

• 1410806-73-3 2-chloro-1-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-ethanone 
• 1410806-35-7 1-[1-(4-Chloro-phenyl)-1H-pyrazol-4-yl]-2-piperidin-1-yl-ethanone 

Relevant academic research and scientific papers

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Design, synthesis, biological evaluation and in silico studies of pyrazole‐based nh2‐acyl oseltamivir analogues as potent neuraminidase inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti‐influenza therapy. The 150‐cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150‐cavity

Discovery and optimization of pyrazole amides as antagonists of CCR1

A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanced ca

PROTEOSTASIS REGULATORS

The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts, prodrugs and solvates thereof, compositions of any of thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis comprising an effective amount of these compounds.

Synthesis and structure - Activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.