138907-80-9Relevant articles and documents
Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks
Ferreira, Byanca Silva,Silva, Rafaela Corrêa,Souto, Bernardo Araújo,Dos Santos, Maurício Silva
, p. 335 - 343 (2021/09/07)
Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.
Discovery and optimization of pyrazole amides as antagonists of CCR1
Harcken, Christian,Sarko, Christopher,Mao, Can,Lord, John,Raudenbush, Brian,Razavi, Hossein,Liu, Pingrong,Swinamer, Alan,Disalvo, Darren,Lee, Thomas,Lin, Siqi,Kukulka, Alison,Grbic, Heather,Patel, Mita,Patel, Monica,Fletcher, Kim,Joseph, David,White, Della,Amodeo, Laura,Berg, Karen,Brown, Maryanne,Thomson, David S.
, p. 435 - 440 (2018/11/23)
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanced ca
Synthesis and structure - Activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors
Ishibuchi, Seigo,Morimoto, Hiroshi,Oe, Takanori,Ikebe, Tsuguo,Inoue, Hiroyoshi,Fukunari, Atsushi,Kamezawa, Miho,Yamada, Ichimaro,Naka, Yoichi
, p. 879 - 882 (2007/10/03)
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.