226067-54-5

Upstream product

• 226067-50-1 N-[(2R,3S)-2-bromo-3-hydroxy-3-phenylpropionyl]-(1S,5R,7R)-10,10-dimethyl-3-thioxo-2-aza-4-oxatricyclo[6.2.1.o^1,5]decane 

Downstream Products

• 274684-20-7 methyl (2R,3S)-2-bromo-3-hydroxy-3-phenylpropanoate 
• 115794-68-8 methyl (2S,3S)-phenylglycidate 

Relevant academic research and scientific papers

Towards the development of oxadiazinanones as chiral auxiliaries: synthesis and application of N3-haloacetyloxadiazinanones

Oxadiazinanones derived from (1R,2S)-ephedrine and (1R,2S)-norephedrine were employed in the asymmetric α-halo aldol reaction. The optimized yields and diastereoselectivities for the ephedrine based oxadiazinanone aldol reaction ranged from fair to good.

Asymmetric bromination-aldolization of chiral acetate titanium enolate derived from thioimide. A general approach to the synthesis of enantiopure α-bromo-β-hydroxy carboxylic acids

Chiral acetate titanium enolate derived from thioimide efficiently effects one-step bromination-aldolization with excellent yields and exceptionally high levels of asymmetric induction in aldol additions. General base promoted oxazolidinethione deacylatio