22612-77-7

Basic information

• Product Name: Cycloheptanone, 2-methyl-2-phenyl-
• CAS NO: 22612-77-7
• Molecular Formula: C14H18O
• Molecular Weight: 202.296
• Mol File: 22612-77-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cycloheptanone, 2-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cycloheptanone, 2-methyl-2-phenyl-(22612-77-7)
• EPA Substance Registry System: Cycloheptanone, 2-methyl-2-phenyl-(22612-77-7)

Safety Data

• Hazardous Substances Data: 22612-77-7(Hazardous Substances Data)

Upstream product

• 7664-93-9 sulfuric acid 
• 1139-06-6 1-hydroxy-α-methyl-α-phenyl-cyclohexanemethanol 
• 22293-10-3 (1-diazoethyl)benzene 
• 108-94-1 cyclohexanone 
• 3674-77-9 2-methyl-2-phenyl-1,3-dioxolane 
• 14996-78-2 2-phenylcycloheptanone 
• 74-88-4 methyl iodide 

Relevant articles and documents

Catalytic diazoalkane-carbonyl homologation: Synthesis of 2,2-diphenylcycloheptanone and other quaternary or tertiary arylalkanones and spirocycles by ring expansion

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Mg-promoted mixed pinacol coupling

Mg-promoted reduction of a mixture of aromatic ketones (or imines) and aliphatic carbonyl compounds in N,N-dimethylformamide (DMF) brought about unique mixed pinacol type of cross coupling to give unsymmetrical vicinal diols (or amino alcohols) or α-hydroxyketones in good to moderate yields. The reaction may be initiated by electron transfer from magnesium metal to an aromatic carbonyl compound possessing a less negative reduction potential. The difference of reduction potential between aromatic ketones (or imines) and aliphatic carbonyl compounds was found to be one of the important key factors in this selective cross coupling.