3674-77-9

Basic information

• Product Name: 1,3-Dioxolane,2-methyl-2-phenyl-(6CI,7CI,8CI,9CI)
• Synonyms: 1,3-Dioxolane,2-methyl-2-phenyl-(6CI,7CI,8CI,9CI);2-Methyl-2-phenyl-1,3-dioxolane;Acetophenone ethylene acetal
• CAS NO: 3674-77-9
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Product Categories: PHENYL
• Mol File: 3674-77-9.mol
• Article Data: 80

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 236.1°C at 760 mmHg
• Flash Point: 97.1°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.0739mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 1,3-Dioxolane,2-methyl-2-phenyl-(6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane,2-methyl-2-phenyl-(6CI,7CI,8CI,9CI)(3674-77-9)
• EPA Substance Registry System: 1,3-Dioxolane,2-methyl-2-phenyl-(6CI,7CI,8CI,9CI)(3674-77-9)

Safety Data

• Hazardous Substances Data: 3674-77-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4605, 1996 DOI: 10.1016/0040-4039(96)00888-X

InChI:InChI=1/C10H12O2/c1-10(11-7-8-12-10)9-5-3-2-4-6-9/h2-6H,7-8H2,1H3

Upstream product

• 107-21-1 ethylene glycol 
• 98-86-2 acetophenone 
• 75-21-8 oxirane 
• 917-54-4 methyllithium 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 108-86-1 bromobenzene 
• 764-48-7 ethyleneglycol vinyl ether 
• 17763-67-6 Phenyl triflate 
• 14517-91-0 4-(2-methyl-[1,3]dioxolan-2-yl)benzonitrile 
• 19073-15-5 2-(4-nitrophenyl)-2-methyl-1,3-dioxolane 
• 75250-64-5 acetophenone 
• 36881-02-4 2-(4-chlorophenyl)-2-methyl-1,3-dioxolane 
• 75-89-8 2,2,2-trifluoroethanol 
• 116-11-0 2-Methoxypropene 

Downstream Products

• 939-55-9 2-chloroethyl benzoate 
• 98-83-9 isopropenylbenzene 
• 588-59-0 stilbene 
• 833-81-8 1,2-diphenylpropene 
• 2510-98-7 2,3-diphenyl-2-butene 
• 15362-40-0 1-(2,6-dichlorophenyl)indolin-2-one 
• 6331-22-2 2-methyl-2-phenyl-[1,3]dithiane 
• 2040-37-1 benzyl 1-phenylethyl ether 
• 4799-66-0 2-(1-phenylethoxy)ethanol 
• 98-85-1 1-Phenylethanol 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 26305-99-7 1-iodo-2-trimethylsilyloxy-ethane 
• 108415-97-0 <1-(2-Hydroxyethoxy)ethenyl>benzene 
• 153632-95-2 <1-(2-n-Butoxyethoxy)ethenyl>benzene 

Relevant articles and documents

Selective Acetalization of ethylene glycol with methyl 2-napthyl ketone over solid acids: Efficacy of acidic clay supported Cs2.5H0.5PW12O40

Catalytic conversion of biomass to value added products is relevant with regard to several industries. Biomass derived ethylene glycol has many applications. Acetalization is used to synthesize valuable chemicals and also occasionally to protect carbonyl

Green efficient synthesis of ketal under catalysis of ionic liquid TTPT

The invention discloses a method for green efficient synthesis of ketal under catalysis of ionic liquid TTPT. The method comprises the following steps: adding TTPT and a water-carrying agent into a raw material I and a raw material II, and carrying out a heating reflux reaction for 110-150 minutes, wherein R1 and R2 in formulas I and II are independently selected from a group consisting of a methyl group, an ethyl group and a phenyl group, or R1 and R2 are connected and cyclized to form a 5-to-10-membered naphthenic base; and R3 is selected from H or-OH. Compared with the prior art, the catalytic yield of the TTPT is remarkably improved, a good catalytic effect is achieved, and experimental operation is easy and convenient.

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.

Synthesis of dioxolanes and oxazolidines by silica gel catalysis

Abstract: Ethylene glycol condensed with carbonyl compounds in the presence of silica gel or alumina, without solvent and under pressure, affords 1,3-dioxolanes. 2-Amino-2-methylpropanol also condensed with carbonyl compounds in the presence of silica gel or an acid-activated clay, without solvent and under pressure, produces oxazolidines. To explain these results, we propose that the glycol and the aminopropanol react with Br?nsted (H+) and Lewis acid sites (Si and Al) located on the surface of the catalysts, leading to the products via various ionic intermediates.