22614-69-3

Usage

Uses

Used in Pharmaceutical Industry:
8-Methoxyquinolin-2(1H)-one is used as an intermediate in the synthesis of metabolites for [application reason] in the treatment of asthma. Specifically, it is involved in the synthesis of procaterol hydrochloride (Meptin), a β2-adrenergic agonist that helps in managing asthma symptoms by relaxing the muscles in the airways and increasing airflow to the lungs.

InChI:InChI=1/C10H9NO2/c1-13-8-4-2-3-7-5-6-9(12)11-10(7)8/h2-6H,1H3,(H,11,12)

Upstream product

• 103203-50-5 2-amino-3-methoxy-trans-cinnamic acid 
• 77432-36-1 N-(3-ethoxyacryloyl)-o-anisidine 
• 74668-74-9 2-chloro-8-methoxy-quinoline 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 67-68-5 dimethyl sulfoxide 
• 938-33-0 8-methoxyquinoline 
• 22614-90-0 8--methoxyquinoline N--oxide 
• 1027166-71-7 6-iodo-2-methoxypivaloylaminobenzene 
• 90-04-0 2-methoxy-phenylamine 
• 33768-49-9 N-(2-methoxyphenyl)pivalamide 
• 126582-57-8 (E)-N-(2-methoxyphenyl)-3-phenylacrylamide 
• 1027916-32-0 methyl trans-3-methoxy-2-pivaloylaminocinnamate 
• 77432-38-3 N-(3,3-di-n-butoxypropionyl)-o-anisidine 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 62978-73-8 5-acetyl-8-hydroxy-2(1H)-quinolinone 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 
• 93609-53-1 5-Acetyl-8-benzyloxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-85-9 oxime de (benzyloxy-8 carbostyrile-5)-1-ethanone 
• 93609-58-6 8-Benzyloxy-5-{1-[(E)-hydroxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-61-1 8-Benzyloxy-5-{1-[(Z)-oxiranylmethoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-70-2 8-Hydroxy-5-{1-[(Z)-2-hydroxy-3-(1-methyl-2-phenyl-ethylamino)-propoxyimino]-ethyl}-1H-quinolin-2-one 
• 93609-73-5 8-Hydroxy-5-{1-[(Z)-2-hydroxy-3-(1-methyl-2-phenyl-ethylamino)-propoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-71-3 5-(1-{(Z)-3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-8-hydroxy-1H-quinolin-2-one 
• 93609-87-1 8-Benzyloxy-5-{1-[(Z)-3-tert-butylamino-2-hydroxy-propoxyimino]-ethyl}-1H-quinolin-2-one 
• 93609-64-4 5-(1-{(Z)-3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-8-methoxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-67-7 8-Benzyloxy-5-(1-{(Z)-3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-3,4-dihydro-1H-quinolin-2-one 
• 199871-96-0 2--bromo--8--methoxyquinoline 
• 188668-92-0 8-Hydroxy-3-(p-tolyl)-1,2-dihydroquinolin-2-one 

Relevant academic research and scientific papers

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.

Selenophenol quinoline derivative as well as preparation method and application thereof

The invention discloses a selenophenol quinoline derivative as well as a preparation method and application thereof. The structure of the selenophenol quinoline derivative is shown as a formula I, a formula II or a formula III, wherein R1 is hydrogen, a C1-6 alkyl group, a C1-6 alkoxy group, a substituted ketone group, a phenyl group, a benzyl group, a substituted phenyl group or a substituted benzyl group; R1 is a monovalent metal cation; R2 is one or more of hydrogen, halogen, a C1-4 alkyl group, a C1-4 alkoxy group or a C1-4 haloalkyl group; R3 is a substituted five-membered heterocyclicring or a substituted six-membered heterocyclic ring; and a heteroatom is one or more of N, O, S or Se. The compound disclosed by the invention is novel in structure, simple in preparation process and relatively good in inhibition effect on various cancer cells, particularly the compounds 34, 44, 45, 98, 104, 115 and 116 have excellent inhibition effects on various cancer cells, the effects of the compounds are equivalent to those of a positive control DDP, and the compounds can be used to prepare anti-cancer drugs to be applied under 5 [mu]M or below, so that the prospect is wide.

DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Preparation of new 3-hydroxyquinoline alkaloid, jineol and its ether derivatives using directed ortho-lithiation of chloroquinoline as the key step

A new alkaloid, jineol (3,8-dihydroxyquinoline) was conveniently prepared employing directed ortho-lithiation of chloroquinoline for 3-position of quinoline ring. Moreover, the ether derivatives of jineol were obtained by the reaction of jineol with alkyl

Regioselectivity of the metalation of polymethoxylated pivaloyl-aminobenzenes. Synthesis of methoxy-2(1H)-quinolones. Precursors of 2-substituted-5,8-quinolinediones

Synthesis of methoxy-2(1H)-quinolones precursors of 2-substituted-5,8-quinolinediones is described. A metalation, Heck coupling reaction and cyclisation sequence is used. Regioselectivity of the metalation of methoxypivaloylaminobenzenes is studied.

Ethers of oximes with a carbostyril ring. IV. Syntheses and β-blocking activities

Syntheses of 12-O-(1-alkylamino-2-propanol)(8-hydroxy or alkoxycarbostyril)-5 methylketone oxime are reported. The beta-adrenergic blocking activity of the 12 compounds was determined in vitro on the trachea and atria of the guinea pig. Structure-activity relationships are discussed.