53899-19-7

Upstream product

• 52749-50-5 3,4-dihydro-8-hydroxy-2(1H)-quinolinone 
• 74-88-4 methyl iodide 
• 22614-69-3 8-methoxy-1H-quinolin-2-one 
• 74668-74-9 2-chloro-8-methoxy-quinoline 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 67363-17-1 N-Hydroxy-3-(3-methoxy-phenyl)-propionamide 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 
• 90-04-0 2-methoxy-phenylamine 
• 55860-23-6 N-(methoxyphenyl)-3-chloropropionamide 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 105910-09-6 ethyl 3-methoxy-2-nitrocinnamate 

Downstream Products

• 93609-53-1 5-Acetyl-8-benzyloxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-58-6 8-Benzyloxy-5-{1-[(E)-hydroxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-61-1 8-Benzyloxy-5-{1-[(Z)-oxiranylmethoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-73-5 8-Hydroxy-5-{1-[(Z)-2-hydroxy-3-(1-methyl-2-phenyl-ethylamino)-propoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-64-4 5-(1-{(Z)-3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-8-methoxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-67-7 8-Benzyloxy-5-(1-{(Z)-3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-3,4-dihydro-1H-quinolin-2-one 

Relevant academic research and scientific papers

Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp2)?H Amidation

Benzofused lactams, especially indolin-2-one and dihydroquinolin-2-one are popular structural motives in durgs and natural products. Herein, we developed a room temperature and robust synthesis of benzofused lactams through cobalt(III)-catalyzed C(sp

Synthesis of Lactams via Ir-Catalyzed C-H Amidation Involving Ir-Nitrene Intermediates

x-membered lactams were synthesized via either an amidation of sp3 C-H bonds or an electrophilic substitution of arenes via Ir-nitrene intermediates. With the employment of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol, a wide range of lactams were synthesized in good to excellent yields with high selectivity.

Revisiting Arene C(sp2)?H Amidation by Intramolecular Transfer of Iridium Nitrenoids: Evidence for a Spirocyclization Pathway

Two mechanistic pathways, that is, electrocyclization and electrophilic aromatic substitution, are operative in most intramolecular C?H amination reactions proceeding by metal nitrenoid catalysis. Reported here is an alternative mechanistic scaffold leading to benzofused δ-lactams selectively. Integrated experimental and computational analysis revealed that the reaction proceeds by a key spirocyclization step followed by a skeletal rearrangement. Based on this mechanistic insight, a new synthetic route to spirolactams has been developed.

DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Ethers of oximes with a carbostyril ring. IV. Syntheses and β-blocking activities

Syntheses of 12-O-(1-alkylamino-2-propanol)(8-hydroxy or alkoxycarbostyril)-5 methylketone oxime are reported. The beta-adrenergic blocking activity of the 12 compounds was determined in vitro on the trachea and atria of the guinea pig. Structure-activity relationships are discussed.