226215-83-4

Upstream product

• 95-55-6 2-amino-phenol 
• 27383-59-1 ethyl (2-hydroxyphenylcarbamoyl)formate 
• 226215-82-3 N-(2'-hydroxyphenyl)-N'-<9S,10R-(10-hydroxy-9-methyl-10-phenyl)ethyl>oxamide 

Downstream Products

• 226215-85-6 (5R,4S,2R,16R)-N,N'-ethylene(4-methyl-5-phenyl-18,23-phenylene)-2,16-bisoxazolidine 

Relevant academic research and scientific papers

A new method for the preparation of unsymmetrical 1,4-substituted piperazine derivatives

Symmetrical and unsymmetrical N,N'-piperazine derivatives of (-)- norephedrine and o-aminophenol were synthesized stereoselectively in yields >70% by reduction of the corresponding N,N'-ethylenebisoxazolidine heterocycles. The stereochemistry at the ring fusion carbons was established by NMR spectroscopy and X-ray crystallography.