226249-18-9Relevant academic research and scientific papers
METHOD FOR PRODUCING ACETOAMIDE PYRROLIDINE DERIVATIVE
-
Page/Page column 8, (2008/06/13)
PROBLEM TO BE SOLVED: To provide a method for producing an acetoamide pyrrolidine derivative useful as a production intermediate for a chemokine receptor antagonist. SOLUTION: The present invention relates to the method for producing the acetoamidepyrrolidine derivatives represented by formulas (wherein R1 and R2 are each independently hydrogen atom or R1 and R2 are each a protective group of an amino group in which R1 and R2 together may form a ring structure; R13, R14, R15 and R16 are each independently hydrogen atom, a halogen atom or a 1-6C alkyl group which may be substituted with a halogen atom, a 1-6C alkoxyl group which may be substituted with a halogen atom or a hydroxy group; R3 is hydrogen atom or a 1-6C alkyl group) or their salts.
Cyclic amine derivatives and their use as drugs
-
, (2008/06/13)
A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1α and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atheroclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES
-
, (2008/06/13)
This invention provides remedies or prophylactics for diseases in association with chemokines such as MIP-1 α and/or MCP-1. Namely, remedies or prophylactics for diseases in association with the chemokines such as rheumatoid arthritis or nephritis contain
