850140-82-8Relevant academic research and scientific papers
PROCESS FOR PRODUCING AMINOPYRROLIDINE DERIVATIVE AND INTERMEDIATE COMPOUND
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Page/Page column 18-19, (2008/06/13)
There is provided an industrial production method of an aminopyrrolidine derivative having chemokine receptor antagonist activity represented by the following formula, a synthetic intermediate thereof and a production method thereof: wherein R11 is H, C1-C6 alkyl or C2-C7 alkanoyl; R12, R14, R15, R16 and R17 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy, hydroxyl or C2-C7 alkoxycarbonyl; R23, R24, R25 and R26 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy or hydroxyl; and R3 is H or C1-C6 alkyl.
METHOD FOR PRODUCING AMINOPYRROLIDINE DERIVATIVE
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Page/Page column 9, (2008/06/13)
PROBLEM TO BE SOLVED: To provide a method for simply and industrially producing a chemokine receptor antagonist. SOLUTION: The present invention relates to a method for producing aminopyrrolidine derivatives represented by formulas (wherein R11 is hydrogen atom, a 1-6C alkyl group or a 2-7C alkanoyl group; R12, R14, R15, R16 and R17 are each independently hydrogen atom, a halogen atom, a 1-6C alkyl group which is substituted with a halogen atom, a 1-6C alkoxyl group which is substituted with a halogen atom, a hydroxy group or a 2-7C alkoxycarbonyl group; R1 and R2 are each independently hydrogen atom or a protective group of an amino group in which R1 and R2 together may form a ring structure; R23, R24, R25 and R26 are each independently hydrogen atom, a halogen atom, a 1-6C alkyl group which may be substituted with a halogen atom, a 1-6C alkoxyl group which may be substituted with a halogen atom or a hydroxy group; R3 is a hydrogen atom or a 1-6C alkyl group) or their salts.
