226256-18-4Relevant academic research and scientific papers
[3+2] cycloaddition reactions of proline benzyl ester nitrone with alkenes and alkynes
Bernotas, Ronald C.,Sabol, Jeffrey S.,Sing, Lily,Friedrich, Dirk
, p. 653 - 655 (1999)
Proline-based nitrone 2a has been synthesized. It readily underwent [3+2] cycloadditions with a variety of alkene and alkyne substrates to give isoxazolidines and isoxazolines, respectively, with good to excellent regio- and diastereoselectivity.
Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols
Clementson, Sebastian,Radaelli, Alessio,Fjelbye, Kasper,Tanner, David,Jessing, Mikkel
supporting information, p. 4763 - 4766 (2019/06/24)
This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).
A metal-free general procedure for oxidation of secondary amines to nitrones
Gella, Carolina,Ferrer, Eric,Alibes, Ramon,Busque, Felix,De March, Pedro,Figueredo, Marta,Font, Josep
supporting information; experimental part, p. 6365 - 6367 (2009/12/24)
(Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functiona
