22631-60-3

Basic information

• Product Name: (2-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE
• Synonyms: ART-CHEM-BB B015351;CHEMBRDG-BB 3015351;AKOS B015351;(2-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE;2-(2-chlorophenyl)acetohydrazide(SALTDATA: FREE);2-(2-chlorophenyl)ethanehydrazide
• CAS NO: 22631-60-3
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 22631-60-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 153-155.5 °C
• Boiling Point: 394.9 °C at 760 mmHg
• Flash Point: 192.6 °C
• Appearance: /
• Density: 1.283 g/cm³
• Vapor Pressure: 1.91E-06mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.78±0.18(Predicted)
• CAS DataBase Reference: (2-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(22631-60-3)
• EPA Substance Registry System: (2-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(22631-60-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 22631-60-3(Hazardous Substances Data)

Usage

General Description

(2-Chloro-phenyl)-acetic acid hydrazide is a synthetic organic compound that falls under the class of phenylacetic acid derivatives. It consists of a phenylacetamide moiety, which includes a phenyl group (a ring of six carbon atoms, also known as an aromatic ring) that is bonded to an acetic acid group. The phenyl ring in this compound is substituted at the second position by a chlorine atom. Additionally, this compound also consists of a hydrazide group, which is a common functional group in organic chemistry. While it is primarily used in research and laboratory settings, its properties may make it useful in the development of pharmaceuticals and other chemical products.

InChI:InChI=1/C8H9ClN2O/c9-7-4-2-1-3-6(7)5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 40061-54-9 2-chlorophenylacetic acid ethyl ester 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 57486-68-7 methyl (2-chlorophenyl)acetate 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Microwave-Assisted Synthesis, Antimicrobial Activity, and SAR Study of 3-(2-Chlorobenzyl)-6-(Substituted Phenyl)-7H-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazines

Abstract: An efficient, simple, and greener method has been described for the synthesis of 3-(2-chlorobenzyl)-6-(substituted phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines by using microwave irradiations. The one-pot reaction between 4-amino-5-(2-chlorobenzyl)-4H-1,2,4-triazole-3-thiol and various phenacyl bromide in the presence of reusable catalyst DABCO and EtOH solvents to give the desired products. We have discovered different organic compounds as antimicrobial agents and study for their structure-activity relationships (SAR). The antimicrobial screening shows moderate activities against used microbes.

Asymmetric Synthesis and Antitumor Activity of Spiro-Oxadiazole Derivatives from 1,4:3,6-Dianhydro-D-fructose

A series of spiro-oxadiazoles were synthesized from 1,4:3,6-dianhydro-D-fructose and hydrazides via a stereo- selective two-step reaction sequence. The structures of newly synthesized compounds were established by spectral analysis. The absolute configuration of compound 2a was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their in vitro antitumor activity, showing that these compounds have poor inhibitory activities against A549, MGC-803 tumor cells.