226416-47-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 95514-03-7 (R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate 
• 95514-04-8 (S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol 
• 91751-24-5 (R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal 

Downstream Products

• 226080-03-1 (E)-(3S,6R,7S)-7-[(2S,4S,5R,6S)-2-(3,4-Dimethoxy-phenyl)-6-((S)-1-methoxymethoxy-2-triethylsilanyloxy-ethyl)-5-methyl-[1,3]dioxan-4-yl]-6-methoxymethoxy-3,5-dimethyl-oct-4-en-2-ol 
• 226079-49-8 (3S,4E,6R,7S,8S,9R,10S,11S)-12-triethylsilyloxy-8,10-<(S)-3,4-dimethoxybenzylidenedioxy>-6,11-bis(methoxymethoxy)-3,5,7,9-tetramethyl-4-dodecen-2-one 
• 226079-68-1 (2S,3S,4R,5S,6S,7R,8E,10S)-11-hydroxy-3,5-<(S)-3,4-dimethoxybenzylidenedioxy>-2,7-bis(methoxymethoxy)-4,6,8,10-tetramethyl-8-undecen-1-yl 2,2-dimethylpropanoate 
• 226080-00-8 2,2-Dimethyl-propionic acid (S)-2-[(2S,4S,5R,6S)-2-(3,4-dimethoxy-phenyl)-6-((E)-(1S,2R,5S)-2-methoxymethoxy-1,3,5-trimethyl-6-oxo-hex-3-enyl)-5-methyl-[1,3]dioxan-4-yl]-2-methoxymethoxy-ethyl ester 
• 226080-01-9 (2S,3S,4R,5S,6S,7R,8E,10S,11RS)-3,5-<(S)-3,4-dimethoxybenzylidenedioxy>-2,7-bis(methoxymethoxy)-4,6,8,10-tetramethyl-8-dodecene-1,11-diol 
• 226079-51-2 (2E,4S)-5-(tert-butyldiphenylsilyloxy)-2-iodo-4-methyl-2-pentene 

Relevant academic research and scientific papers

Synthetic studies of the 18-membered antitumor macrolide, tedanolide. 3. Stereocontrolled synthesis of the C1-C12 part via a synthesis of the C1-C7 fragment by a mismatched but efficient sharpless dihydroxylation and its coupling with the C8-C11 fragment

The C1-C12 part (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methylpropionate (11a) via a coupling between the C1- C7 aldehyde (6) and the C8-C11 iodoalkene (7a). For a synthesis of 6, a mismatched but highly efficient Sharpless dihydroxylation of the α,β- unsaturated ester (15) with AD-mix-α was successfully applied. Compound 7a was synthesized using hydrozirconation to the alkyne (32).