226420-39-9

Basic information

• Product Name: 1,4,7,10-tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane
• Synonyms: 1,4,7,10-tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane
• CAS NO: 226420-39-9
• Molecular Weight: 760.98
• Mol File: 226420-39-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4,7,10-tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane(226420-39-9)
• EPA Substance Registry System: 1,4,7,10-tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane(226420-39-9)

Safety Data

• Hazardous Substances Data: 226420-39-9(Hazardous Substances Data)

Upstream product

• 64297-96-7 N-(iodoacetyl)benzylamine 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 100-46-9 benzylamine 
• 2945-03-1 N-benzyl-2-bromoacetamide 

Relevant articles and documents

Efficient separation of perrhenate as analogue to pertechnetate in nitric acid solution with a DOTA-tetraamide ligand: Solvent extraction, complexation and structure study

The two DOTA-tetraamide ligands, DOTAM-n-butyl (1,4,7,10-tetrakis[(N-n-butyl; carbamoyl)methyl]-1,4,7,10-tetraazacyclododecane) and DOTAM-benzyl (1,4,7,10- tetrakis[(N-benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododecane), were synthesized and character

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands-A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.