22649-27-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-5,7-dihydroxy-4-methyl-2H-chromen-2-one is used as a potential drug candidate for its biological and pharmacological activities. Its antioxidant and anti-inflammatory properties make it a promising compound for the development of new drugs targeting various diseases and conditions.
Used in Research and Development:
3-Chloro-5,7-dihydroxy-4-methyl-2H-chromen-2-one serves as a valuable research tool in the study of chromenone derivatives. Its unique structure and properties allow scientists to explore its potential applications and mechanisms of action, contributing to the understanding of chromenone chemistry and its implications in drug discovery and development.

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Relevant academic research and scientific papers

Nano-BFn/cellulose: a bio-based nano-catalyst for synthesis of bio-active 7-hydroxycoumarins

Nano-BFn/cellulose as a modified bio-based nano-catalyst has been synthesized from nanocellulose and boron triflouride via very simple steps. This novel nano-catalyst exhibited many advantages in the synthesis of 7-hydroxycoumarins such as good

Preparation of coumarin derivative thereof for the application of the major diseases in the brain

The invention discloses novel coumarin compounds and pharmaceutically acceptable salts thereof, the preparation method of the compounds, pharmaceutical compositions containing the compounds, and application of the compounds to preparation of medicaments for prevention or treatment of cerebral diseases, especially prevention or treatment of diseases related to neuron damage and neuroinflammation, and prevention or treatment of Parkinson's disease, dementia, cerebral ischemia, depression and cerebral apoplexy.

TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF

The present invention relates to tctracyclodipyrano-coumarin compounds of general formula (I), wherein the substituents are defined herein. These compounds exihibit dual biological activities of anti human immunodeficiency virus type 1 (HIV-1) infection a

Discovery and optimization of novel 3-piperazinylcoumarin antagonist Of chemokine-like factor 1 with oral antiasthma activity in mice

Chemokine-like factor 1 (CKLF1) is a novel functional cytokine that acts through its receptor CC chemokine receptor 4 (CCR4). Activation of CCR4 by CKLF1 plays an important role in diseases such as asthma and multiple sclerosis. This article describes a cell-based screening assay using an FITC-labeled CCR4 agonist (CKLF1-C27), a CKLF1 peptide fragment. Screening of our in-stock smallmolecule library identified a 3-piperazinylcoumarin analogue 1 (IC 50 = 4.36 × 10-6 M) that led to the discovery of orally active compound, 41 (IC50 = 2.12 × 10-8 M) through systematic optimization. Compound 41 blocked the calcium mobilization and Chemotaxis induced, by CKLF1-C27 and reduced the asthmatic pathologic changes in lung tissue of human CKLF1-transfected mice. Further studies indicated that compound 41 ameliorated pathological changes via inhibition of the NF-κB signal pathway.

KAl(SO4)2·12H2O (alum) a reusable catalyst for the synthesis of some 4-substituted coumarins via Pechmann reaction under solvent-free conditions

A simple, efficient, and practical procedure for the Pechmann condensation using KAl(SO4)2·12H2O (alum) as a non-toxic, reusable, inexpensive, and easily available catalyst is described under solvent-free condition at 65°C. These improved reaction conditions allow the preparation of a wide variety of some new substituted coumarins in high yields (86-96%) and purity under mild reaction conditions. Compared to the classical Pechmann condensation, this new method consistently has the advantage of high yields.

Zirconyl chloride: A useful catalyst in the Pechmann coumarin synthesis

Coumarin derivatives were prepared using zirconyl chloride octahydrate (1%) as a Pechmann catalyst, either neat or in some cases employing small volumes of ethanol as solvent. As result of this work, coumarins were obtained in moderate to good yields. Georg Thieme Verlag Stuttgart.

Sulfated zirconia, a mild alternative to mineral acids in the synthesis of hydroxycoumarins

Sulfated zirconia (1%) was employed as Pechmann's catalyst without solvent or in some cases using a small amount of ethanol to obtain coumarins in moderate to good yields. With this procedure, no significant acidic waste was obtained and an environmental friendly alternative to obtain coumarins is provided.