22649-30-5Relevant academic research and scientific papers
Design of High-Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface
Alontaga, Aileen Y.,Li, Yifei,Chen, Chih-Hong,Ma, Chen-Ting,Malany, Siobhan,Key, Danielle E.,Sergienko, Eduard,Sun, Qing,Whipple, David A.,Matharu, Daljit S.,Li, Baozong,Vega, Ramir,Li, Yi-Jia,Schoenen, Frank J.,Blagg, Brian S. J.,Chung, Thomas D.Y.,Chen, Yuan
, p. 239 - 246 (2015)
Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multidisciplinary approach to identify small-molecule disruptors of protein-protein interactions that are mediated by SUMO (small
Structural Elucidation of Selective Solvatochromism in a Responsive-at-Metal Cyclometalated Platinum(II) Complex
Andrews, Ryan J.,Carta, Veronica,Chaudhry, Mohammad T.,MacLachlan, Mark. J.,Soto, Miguel A.
supporting information, p. 10348 - 10352 (2020/05/25)
We report the synthesis, characterization, and spectroscopic investigations of a new responsive-at-metal cyclometalated platinum(II) complex. With mild chemical oxidants and reductants, it was possible to obtain the same complex in three different oxidati
Synthesis, Activity, and Molecular Modeling Studies of Novel Human Aldose Reductase Inhibitors Based on a Marine Natural Product
De La Fuente, Jesús ángel,Manzanaro, Sonia,Martín, María Jesús,De Quesada, Teresa G.,Reymundo, Isabel,Luengo, Santos M.,Gago, Federico
, p. 5208 - 5221 (2007/10/03)
Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications, the discovery of new ALR2 inhibitor
Allosteric Interaction of Metal Ions with Saccharides in a Crowned Diboronic Acid
Deng, Gang,James, Tony D.,Shinkai, Seiji
, p. 4567 - 4572 (2007/10/02)
A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are succesfully coupled in an allosteric system.The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD).Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity.This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.
