226545-90-0

Downstream Products

• 226546-08-3 (3R,6S,8aS)-6-Allyl-6-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-allyl]-2,2,8a-trimethyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione 
• 1027962-47-5 6-allyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-but-2-enylsulfanyl]-2,2,8a-trimethyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 226546-04-9 (R)-4-Allyl-4-[(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-allyl]-cyclohex-2-enone 
• 226546-05-0 (1S,5R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-spiro[4.5]deca-2,6-dien-8-one 
• 1026007-83-9 (3R,8aS)-6-Allyl-5-[((E)-but-2-enyl)sulfanyl]-2,2,8a-trimethyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 226545-97-7 (6S)-6-allyl-6-((3S)-but-1-en-3-yl)-3-methylcyclohex-2-enone 
• 226545-94-4 (4R)-4-allyl-4-((3S)-but-1-en-3-yl)cyclohex-2-enone 

Relevant academic research and scientific papers

An efficient, asymmetric synthesis of (+)-euphococcinine

The enantioselective synthesis of (+)-euphococcinine (1), a homotropane alkaloid, has been achieved in five steps from bicyclic lactam 5. (C) 2000 Elsevier Science Ltd.

An asymmetric route to novel chiral cyclohexenones with spiro-connected cyclopentenes. Further utility of chiral bicyclic thiolactams and the [3,3] thio-Claisen products

Sequential allylation of chiral, nonracemic thiolactam 8 affords clean thio-Claisen [3,3] products 11. The stereoselectivity of the rearrangement was found to be on the order of 10-11:1, with the exo-endo products responsible for the mixture. Addition of hydride or methyllithium-cerium chloride gave clean addition to the thiolactam in the form of its iminium salts 12. Hydrolysis gave 4,4-dialkylcyclohexenones 15, which were cyclized to the cyclopentene derivatives 16 using Grubbs' catalyst.