226570-99-6Relevant academic research and scientific papers
A short synthesis of γ-lycorane using Ni/AcOH mediated radical cyclisation
Cassayre, Jér?me,Zard, Samir Z.
, p. 501 - 503 (1999)
A short synthesis of (±)-γ-lycorane 6 is described using two different radical cyclisations. The key step is the formation of tetrahydroindolone 9 by a nickel-promoted 5-endo radical cyclisation. This is followed by a tributylstannane-mediated 6-endo ring closure to the tetracyclic lactam 10 which is readily reduced tb (±)-γ-lycorane 6.
