2268-14-6

Basic information

• Product Name: 2-(Trifluoromethyl)-3H-purin-6(7H)-one
• Synonyms: 2-(Trifluoromethyl)-3H-purin-6(7H)-one;2-(trifluoromethyl)-7H-purin-6-ol;2-Trifluoromethyl-1,9-dihydro-purin-6-one;2-(trifluoromethyl)-6,9-dihydro-1H-purin-6-one
• CAS NO: 2268-14-6
• Molecular Formula: C6H3F3N4O
• Molecular Weight: 204.1094296
• Mol File: 2268-14-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Trifluoromethyl)-3H-purin-6(7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trifluoromethyl)-3H-purin-6(7H)-one(2268-14-6)
• EPA Substance Registry System: 2-(Trifluoromethyl)-3H-purin-6(7H)-one(2268-14-6)

Safety Data

• Hazardous Substances Data: 2268-14-6(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)-3H-purin-6(7H)-one is a chemical compound that belongs to the purine derivative class. It is a heterocyclic compound containing a purine ring with a trifluoromethyl group at the 2-position and a ketone group at the 6(7)-position. 2-(Trifluoromethyl)-3H-purin-6(7H)-one has been studied for its potential biological and pharmacological properties, including its use in medicinal chemistry as a building block in the synthesis of pharmaceutical drugs. Its unique structure and properties make it a valuable compound for further research and development in the field of drug discovery and pharmaceutical science.

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 

Downstream Products

• 1998-63-6 6-chloro-2-(trifluoromethyl)-9H-purine 
• 122488-18-0 [9-(3-Benzyloxy-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 
• 122488-06-6 [9-(4-Benzyloxy-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 
• 122488-44-2 [9-(4-Chloro-3-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 
• 122488-35-1 [9-(4-Chloro-2-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 
• 122488-02-2 4-(6-Dimethylamino-2-trifluoromethyl-purin-9-ylmethyl)-benzoic acid ethyl ester 
• 122488-20-4 3-(6-Dimethylamino-2-trifluoromethyl-purin-9-ylmethyl)-benzoic acid methyl ester 
• 122487-97-2 Dimethyl-[9-(4-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-amine 
• 122488-22-6 Dimethyl-[9-(3-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-amine 
• 122488-30-6 Dimethyl-[9-(2-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-amine 
• 122488-87-3 6-Chloro-9-(4-chloro-3-nitro-benzyl)-2-trifluoromethyl-9H-purine 
• 122488-79-3 6-Chloro-9-(4-chloro-2-nitro-benzyl)-2-trifluoromethyl-9H-purine 

Relevant articles and documents

Preparation method for 2-trifluoromethyl-6-aminopurine

The invention relates to a preparation method for 2-trifluoromethyl-6-aminopurine. The method comprises the following steps: performing a condensation reaction on 4-formyl-5-aminoimidazole and trifluoroacetamide to obtain a compound 1; performing a chlorination reaction on the compound 1 to obtain a compound 2; performing an ammonolysis reaction on the compound 2 and ammonia in an aminolysis reaction solvent; and after the reaction is completed, performing concentration to dryness, adding a solvent, and performing filtration to obtain the 2-trifluoromethyl-6-aminopurine. The preparation methodprovided by the invention has the advantages that raw materials are cheap and easy to obtain, the synthetic steps are simple, the yield is high, the costs are low and the method is suitable for enlarged production.

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.