1998-63-6

Basic information

• Product Name: 6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE
• Synonyms: IFLAB-BB F2124-0879;6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE;6-Chloro-2-trifluoromethyl-7H-purine;6-Chloro-2-(trifluoromethyl)purine
• CAS NO: 1998-63-6
• Molecular Formula: C₆H₂ClF₃N₄
• Molecular Weight: 222.56
• Mol File: 1998-63-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 204.3°Cat760mmHg
• Flash Point: 77.4°C
• Appearance: /
• Density: 1.94g/cm³
• Vapor Pressure: 0.379mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE(1998-63-6)
• EPA Substance Registry System: 6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE(1998-63-6)

Safety Data

• Hazardous Substances Data: 1998-63-6(Hazardous Substances Data)

Usage

General Description

6-Chloro-2-(trifluoromethyl)-9H-purine is a chemical compound with the molecular formula C7H4ClF3N4. It is a purine derivative with a chlorine atom at the 6-position and a trifluoromethyl group at the 2-position. 6-CHLORO-2-(TRIFLUOROMETHYL)-9H-PURINE is a synthetic analog of natural purines and is used in pharmaceutical research. It has been studied for its potential pharmacological activities, including antiviral and antitumor properties. Additionally, it has been investigated for its potential as a building block for novel therapeutic agents. The presence of the trifluoromethyl group in this compound makes it a valuable synthetic intermediate for the preparation of various pharmaceuticals and agrochemicals.

InChI:InChI=1/C6H2ClF3N4/c7-3-2-4(12-1-11-2)14-5(13-3)6(8,9)10/h1-2H

Upstream product

• 2268-14-6 2-trifluoromethyl-1,7-dihydro-purin-6-one 
• 354-38-1 2,2,2-trifluoroacetamide 
• 360-97-4 4-amino-5-imidazolecarboxamide 
• 2268-14-6 1,9-dihydro-2-(trifluoromethyl)-6H-purin-6-one 

Downstream Products

• 122488-67-9 3-(6-Chloro-2-trifluoromethyl-purin-9-ylmethyl)-benzoic acid methyl ester 
• 122488-57-7 6-Chloro-2-trifluoromethyl-9-(4-trifluoromethyl-benzyl)-9H-purine 
• 122488-59-9 6-Chloro-9-(4-nitro-benzyl)-2-trifluoromethyl-9H-purine 
• 122488-72-6 6-Chloro-9-(2-nitro-benzyl)-2-trifluoromethyl-9H-purine 
• 122488-70-4 6-chloro-9-(2-fluorobenzyl)-2-(trifluoromethyl)purine 
• 122488-64-6 9-(4-Bromo-benzyl)-6-chloro-2-trifluoromethyl-9H-purine 
• 122488-55-5 6-Chloro-9-(4-chloro-benzyl)-2-trifluoromethyl-9H-purine 
• 122488-61-3 6-Chloro-9-(4-fluoro-benzyl)-2-trifluoromethyl-9H-purine 
• 122488-66-8 6-Chloro-9-(3-fluoro-benzyl)-2-trifluoromethyl-9H-purine 
• 105183-02-6 6-chloro-9-(4-methylbenzyl)-2-(trifluoromethyl)-9H-purine 
• 122488-79-3 6-Chloro-9-(4-chloro-2-nitro-benzyl)-2-trifluoromethyl-9H-purine 

Relevant articles and documents

PHOSPHODIESTERASE 4 INHIBITORS

PDE4 inhibition is achieved by novel compounds of the Formula (I), wherein R1 and R2 are as defined herein.

Phosphodiesterase 4 inhibitors

PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.